Grimm's Hydride Displacement Law is an early hypothesis, formulated in 1925, to describe

bioisosterism In medicinal chemistry, bioisosteres are chemical substituents or groups with similar physical or chemical properties which produce broadly similar biological properties to another chemical compound. In drug design, the purpose of exchanging one bi ...

, the ability of certain chemical groups to function as or mimic other chemical groups. :“Atoms anywhere up to four places in the periodic system before an inert gas change their properties by uniting with one to four hydrogen atoms, in such a manner that the resulting combinations behave like pseudoatoms, which are similar to elements in the groups one to four places respectively, to their right.” According to Grimm, each vertical column (of Table below) would represent a group of

isostere Classical Isosteres are molecules or ions with similar shape and often electronic properties. Many definitions are available. but the term is usually employed in the context of bioactivity and drug development. Such biologically-active compounds co ...

References

# Grimm, H. G. ''Structure and Size of the Non-metallic Hydrides'' ''Z. Electrochem.'' 1925, ''31'', 474–480. # Grimm, H. G. ''On the Systematic Arrangement of Chemical Compounds from the Perspective of Research on Atomic Composition; and on Some Challenges in Experimental Chemistry.'' ''Naturwissenschaften'' 1929, ''17'', 557–564. # Patani, G. A.; LaVoie, E. J. ''Bioisosterism: A Rational Approach in Drug Design.'' ''

Chem. Rev. ''Chemical Reviews'' is peer-reviewed scientific journal published twice per month by the American Chemical Society. It publishes review articles on all aspects of chemistry. It was established in 1924 by William Albert Noyes (University of Illinoi ...

'' 1996, ''96'', 3147–3176. ( ) Medicinal chemistry Hydrides {{medicinal-chem-stub