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Grape therapy or grape diet, also known as ampelotherapy, is a diet that involves heavy consumption of grapes, including seeds, and parts of the vine, including leaves, that is a form of
alternative medicine Alternative medicine is any practice that aims to achieve the healing effects of medicine despite lacking biological plausibility, testability, repeatability, or evidence from clinical trials. Complementary medicine (CM), complementary and alt ...
. The concept was developed in the
19th century The 19th (nineteenth) century began on 1 January 1801 ( MDCCCI), and ended on 31 December 1900 ( MCM). The 19th century was the ninth century of the 2nd millennium. The 19th century was characterized by vast social upheaval. Slavery was abolis ...
Germany in
spa A spa is a location where mineral-rich spring water (and sometimes seawater) is used to give medicinal baths. Spa towns or spa resorts (including hot springs resorts) typically offer various health treatments, which are also known as balneoth ...
s like Bad Duerkheim or
Merano Merano (, , ) or Meran () is a city and ''comune'' in South Tyrol, northern Italy. Generally best known for its spa resorts, it is located within a basin, surrounded by mountains standing up to above sea level, at the entrance to the Passeier V ...
. The concept has no scientific basis and is regarded as
quackery Quackery, often synonymous with health fraud, is the promotion of fraudulent or ignorant medical practices. A quack is a "fraudulent or ignorant pretender to medical skill" or "a person who pretends, professionally or publicly, to have skill, ...
by scientific institutions like the
American Cancer Society The American Cancer Society (ACS) is a nationwide voluntary health organization dedicated to eliminating cancer. Established in 1913, the society is organized into six geographical regions of both medical and lay volunteers operating in more than ...
.


Background

An assumption of some of grape therapy is that consuming grape constituents would provide unusual therapeutic or nutritional benefits. However, consuming grapes has unknown effects against
cardiovascular disease Cardiovascular disease (CVD) is a class of diseases that involve the heart or blood vessels. CVD includes coronary artery diseases (CAD) such as angina and myocardial infarction (commonly known as a heart attack). Other CVDs include stroke, h ...
s and other diseases, such as
metabolic syndrome Metabolic syndrome is a clustering of at least three of the following five medical conditions: abdominal obesity, high blood pressure, high blood sugar, high serum triglycerides, and low serum high-density lipoprotein (HDL). Metabolic syndrome ...
. Alternative medicine practitioners have recommended grapes and parts of the vine for treating various diseases, but there is no clinical evidence for any such effects. Grape
pomace Pomace ( ), or marc (; from French ''marc'' ), is the solid remains of grapes, olives, or other fruit after pressing for juice or oil. It contains the skins, pulp, seeds, and stems of the fruit. Grape pomace has traditionally been used to prod ...
contains various
micronutrient Micronutrients are nutrient, essential dietary elements required by organisms in varying quantities throughout life to orchestrate a range of physiological functions to maintain health. Micronutrient requirements differ between organisms; for exam ...
s, but the resulting
flour Flour is a powder made by grinding raw grains, roots, beans, nuts, or seeds. Flours are used to make many different foods. Cereal flour, particularly wheat flour, is the main ingredient of bread, which is a staple food for many culture ...
from pomace has variable nutrient contents due to processing, drying, and storage conditions. Raw grapes are mostly devoid of nutritional benefit, except for moderate amounts of
carbohydrate In organic chemistry, a carbohydrate () is a biomolecule consisting of carbon (C), hydrogen (H) and oxygen (O) atoms, usually with a hydrogen–oxygen atom ratio of 2:1 (as in water) and thus with the empirical formula (where ''m'' may or ma ...
s and
vitamin K Vitamin K refers to structurally similar, fat-soluble vitamers found in foods and marketed as dietary supplements. The human body requires vitamin K for post-synthesis modification of certain proteins that are required for blood coagulation ...
(see grape nutrition).
Proanthocyanidin Proanthocyanidins are a class of polyphenols found in many plants, such as cranberry, blueberry, and grape seeds. Chemically, they are oligomeric flavonoids. Many are oligomers of catechin and epicatechin and their gallic acid esters. More complex ...
s,
anthocyanin Anthocyanins (), also called anthocyans, are water-soluble vacuolar pigments that, depending on their pH, may appear red, purple, blue, or black. In 1835, the German pharmacist Ludwig Clamor Marquart gave the name Anthokyan to a chemical compo ...
s and
resveratrol Resveratrol (3,5,4′-trihydroxy-''trans''-stilbene) is a stilbenoid, a type of natural phenol, and a phytoalexin produced by several plants in response to injury or when the plant is under attack by pathogens, such as bacteria or fungi. Sources ...
extract An extract is a substance made by extracting a part of a raw material, often by using a solvent such as ethanol, oil or water. Extracts may be sold as tinctures, absolutes or in powder form. The aromatic principles of many spices, nuts, h ...
ed from
grape seed A grape is a fruit, botanically a berry, of the deciduous woody vines of the flowering plant genus ''Vitis''. Grapes are a non- climacteric type of fruit, generally occurring in clusters. The cultivation of grapes began perhaps 8,000 years ago ...
s and
grape skin A grape is a fruit, botanically a berry, of the deciduous woody vines of the flowering plant genus ''Vitis''. Grapes are a non- climacteric type of fruit, generally occurring in clusters. The cultivation of grapes began perhaps 8,000 years ago, ...
s are under basic research for their possible biological effects. Pomace also contains
organic acid An organic acid is an organic compound with acidic properties. The most common organic acids are the carboxylic acids, whose acidity is associated with their carboxyl group –COOH. Sulfonic acids, containing the group –SO2OH, are rel ...
s ( tartaric, malic, citric, tannic), but there is no evidence for health effects from these phytochemicals.


History

The documentation of a grape diet was first seen in a publication by Dr. Veit Kaufmann, a family docter in the viticultural city of Bad Duerkheim, Germany, called “Die Traubenkur in Dürkheim a.d. Haardt” (The Grape Treatment Course in Duerkheim at Haardt River) (1856). Kaufmann was well known locally, and a personal friend of
Rudolph Virchow Rudolf Ludwig Carl Virchow (; or ; 13 October 18215 September 1902) was a German physician, anthropologist, pathologist, prehistorian, biologist, writer, editor, and politician. He is known as "the father of modern pathology" and as the founde ...
, who underwent the treatment regularly. In the
USSR The Soviet Union,. officially the Union of Soviet Socialist Republics. (USSR),. was a transcontinental country that spanned much of Eurasia from 1922 to 1991. A flagship communist state, it was nominally a federal union of fifteen nationa ...
, the principles of a grape cure were developed in the 1920s by a group of physicians of the Semashko Institute (Yalta), headed by A.V. D'iakov. Ampelotherapy is offered in alternative medicine clinics and spas, particularly in Europe, together with vinotherapy, a cosmetic treatment that involves rubbing grapes into the skin.
Johanna Brandt Johanna Brandt (18 November 1876 in Heidelberg, Gauteng, Heidelberg, South African Republic – 13 January 1964 in Newlands, Cape Town) was a South African propagandist of Afrikaners, Afrikaner nationalism, spy during the Boer War, prophet and ...
, a South African author, popularized the grape diet as a treatment for cancer from 1925. She published about twenty pamphlets on the subject of natural remedies for health problems with her book ''The Grape Cure'', which is said to have been written after Brandt had cured herself of stomach cancer by following the diet. The book was republished in 1989 as ''How to Conquer Cancer, Naturally'', including an endorsement of Brandt's work by
Benedict Lust Benedict Lust (February 3, 1872 – September 5, 1945) was a German-born American who was one of the founders of naturopathic medicine in the first decades of the twentieth century. Biography Lust was born in Michelbach, Baden, Germany.Anonymou ...
, who is commonly referred to as "the father of naturopathy". Although commonly used as a
dietary supplement A dietary supplement is a manufactured product intended to supplement one's diet by taking a pill, capsule, tablet, powder, or liquid. A supplement can provide nutrients either extracted from food sources or that are synthetic in order ...
and studied in human trials at amount much higher than can be consumed from drinking red wine, there is no high-quality evidence that resveratrol provides any benefits for cardiovascular risk factors. Advocates of grape therapy argue that grape phytochemicals inhibit the development of
cancer Cancer is a group of diseases involving abnormal cell growth with the potential to invade or spread to other parts of the body. These contrast with benign tumors, which do not spread. Possible signs and symptoms include a lump, abnormal b ...
,
arthritis Arthritis is a term often used to mean any disorder that affects joints. Symptoms generally include joint pain and stiffness. Other symptoms may include redness, warmth, swelling, and decreased range of motion of the affected joints. In som ...
or
diabetes Diabetes, also known as diabetes mellitus, is a group of metabolic disorders characterized by a high blood sugar level ( hyperglycemia) over a prolonged period of time. Symptoms often include frequent urination, increased thirst and increased ap ...
, but there is no scientific evidence for such effects.


Treatments

The diet proposed by Veit Kaufmann recommended the consumption of several pounds of freshly picked grapes a day, spread over 4 portions, combined with walks, sports and light healthy meals, over a course of three to six weeks in a spa, overseen by medical personnel. The diet proposed by Johanna Brandt recommended fasting for two or three days, consuming only cold water, followed by a diet of only grapes and water for one to two weeks, with seven meals a day. Fresh fruits, tomatoes, and sour milk or cottage cheese are then introduced to the diet followed by raw vegetables.


Criticisms

Available scientific evidence does not support claims that a diet of grapes is alone effective for treating cancer or any other disease. The Brandt diet, in particular, has been described as “quackery” by Barrett who notes that the
American Cancer Society The American Cancer Society (ACS) is a nationwide voluntary health organization dedicated to eliminating cancer. Established in 1913, the society is organized into six geographical regions of both medical and lay volunteers operating in more than ...
reviewed ''The Grape Cure'' in 1965, 1971, 1974, and 2000 and found no evidence of benefit against human cancer or any other disease. Grape seed extract has been identified by the U.S.
Food and Drug Administration The United States Food and Drug Administration (FDA or US FDA) is a List of United States federal agencies, federal agency of the United States Department of Health and Human Services, Department of Health and Human Services. The FDA is respon ...
as a "fake cancer 'cure'".


See also

*
Urine therapy Urine therapy or urotherapy, (also urinotherapy, Shivambu, uropathy, or auto-urine therapy) in alternative medicine is the application of human urine for medicinal or cosmetic purposes, including drinking of one's own urine and massaging one' ...
*
Gerson therapy Max Gerson (October 18, 1881 – March 8, 1959) was a German-born American physician who developed the Gerson Therapy, a dietary-based alternative cancer treatment that he claimed could cure cancer and most chronic, degenerative diseases. ...
*
List of unproven and disproven cancer treatments This is a non-exhaustive list of alternative treatments that have been promoted to treat or prevent cancer in humans but which lack scientific and medical evidence of effectiveness. In many cases, there is scientific evidence that the alleged tr ...


References

{{Authority control Alternative cancer treatments
Therapy A therapy or medical treatment (often abbreviated tx, Tx, or Tx) is the attempted remediation of a health problem, usually following a medical diagnosis. As a rule, each therapy has indications and contraindications. There are many different ...
Naturopathy Pseudoscience