Glycoprotein IX (platelet) (GP9) also known as CD42a (Cluster of Differentiation 42a), is a human
gene.
Platelet glycoprotein IX (GP9) is a small membrane glycoprotein found on the surface of human platelets. It forms a 1-to-1 noncovalent complex with
glycoprotein Ib (GP Ib), a platelet surface membrane glycoprotein complex that functions as a receptor for
von Willebrand factor (VWF; MIM 193400) (known as the
Glycoprotein Ib-IX-V Receptor Complex The GPIb-IX-V complex is a profuse membrane Cell surface receptor, receptor complex originating in megakaryocytes and exclusively functional on the surface of platelets. It primarily functions to mediate the first critical step in platelet adhesion, ...
). The main portion of the receptor is a heterodimer composed of 2 polypeptide chains, an alpha chain (GP1BA; MIM 606672) and a beta chain (GP1BB; MIM 138720), that are linked by disulfide bonds. The complete receptor complex includes noncovalent association of the alpha and beta subunits with GP9 and platelet
glycoprotein V (GP5; MIM 173511).
upplied by OMIMref name="entrez" />
See also
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Cluster of differentiation
References
Further reading
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External links
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Clusters of differentiation
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