Gopalasamudram Narayanan Ramachandran, or G.N. Ramachandran, FRS (8 October 1922 – 7 April 2001) was an Indian

physicist A physicist is a scientist who specializes in the field of physics, which encompasses the interactions of matter and energy at all length and time scales in the physical universe. Physicists generally are interested in the root or ultimate caus ...

who was known for his work that led to his creation of the

Ramachandran plot In biochemistry, a Ramachandran plot (also known as a Rama plot, a Ramachandran diagram or a �,ψplot), originally developed in 1963 by G. N. Ramachandran, C. Ramakrishnan, and V. Sasisekharan, is a way to visualize energetically allowed region ...

for understanding

peptide Peptides (, ) are short chains of amino acids linked by peptide bonds. Long chains of amino acids are called proteins. Chains of fewer than twenty amino acids are called oligopeptides, and include dipeptides, tripeptides, and tetrapeptides. A ...

structure. He was the first to propose a triple-helical model for the structure of

collagen Collagen () is the main structural protein in the extracellular matrix found in the body's various connective tissues. As the main component of connective tissue, it is the most abundant protein in mammals, making up from 25% to 35% of the whole ...

. He subsequently went on to make other major contributions in

biology Biology is the scientific study of life. It is a natural science with a broad scope but has several unifying themes that tie it together as a single, coherent field. For instance, all organisms are made up of cells that process hereditary i ...

and

physics Physics is the natural science that studies matter, its fundamental constituents, its motion and behavior through space and time, and the related entities of energy and force. "Physical science is that department of knowledge which r ...

Early life and education

Ramachandran was born in the town of

Ernakulam Ernakulam () is the Central Business District of the city of Kochi in Kerala, India and has lent its name to the Ernakulam district. Many major establishments, including the Kerala High Court, the office of the Kochi Municipal Corporation a ...

Kingdom of Cochin The Kingdom of Cochin, named after its capital in the city of Kochi (Cochin), was a kingdom in the central part of present-day Kerala state. It commenced at the early part of the 12th century and continued to rule until 1949, when monarchy w ...

India India, officially the Republic of India (Hindi: ), is a country in South Asia. It is the seventh-largest country by area, the second-most populous country, and the most populous democracy in the world. Bounded by the Indian Ocean on the so ...

to a

Tamil Brahmin Tamil Brahmins are an ethnoreligious community of Tamil-speaking Hindu Brahmins, predominantly living in Tamil Nadu, though they number significantly in Telangana, Andhra Pradesh, Kerala, Karnataka, in addition to other regions of India, as wel ...

family. He completed his BSc honours in Physics from St Joseph's College, Tiruchirappalli in 1939. He joined the

Indian Institute of Science The Indian Institute of Science (IISc) is a public, deemed, research university for higher education and research in science, engineering, design, and management. It is located in Bengaluru, in the Indian state of Karnataka. The institute wa ...

Bangalore Bangalore (), officially Bengaluru (), is the capital and largest city of the Indian state of Karnataka. It has a population of more than and a metropolitan population of around , making it the third most populous city and fifth most ...

in 1942 in the Electrical Engineering Department. Quickly realising his interest in physics, he switched to the Department of Physics to complete his master's and doctoral thesis under the supervision of Nobel laureate

Sir C. V. Raman Sir Chandrasekhara Venkata Raman (; 7 November 188821 November 1970) was an Indian physicist known for his work in the field of light scattering. Using a spectrograph that he developed, he and his student K. S. Krishnan discovered that when ...

. In 1942, he received a master's degree in

from

Madras University The University of Madras (informally known as Madras University) is a public state university in Chennai, Tamil Nadu, India. Established in 1857, it is one of the oldest and among the most prestigious universities in India, incorporated by an a ...

with his thesis submitted from Bangalore (he did not attend any Madras college at that time). He subsequently received his

D.Sc. Doctor of Science ( la, links=no, Scientiae Doctor), usually abbreviated Sc.D., D.Sc., S.D., or D.S., is an academic research degree awarded in a number of countries throughout the world. In some countries, "Doctor of Science" is the degree used f ...

degree in 1947. Here he mostly studied crystal physics and

crystal optics Crystal optics is the branch of optics that describes the behaviour of light in '' anisotropic media'', that is, media (such as crystals) in which light behaves differently depending on which direction the light is propagating. The index of refrac ...

. During his studies he created an X-ray focusing mirror for the

X-ray microscope An X-ray microscope uses electromagnetic radiation in the soft X-ray band to produce magnified images of objects. Since X-rays penetrate most objects, there is no need to specially prepare them for X-ray microscopy observations. Unlike visible li ...

. The resulting field of crystal topography is used extensively in studies involving

crystal growth A crystal is a solid material whose constituent atoms, molecules, or ions are arranged in an orderly repeating pattern extending in all three spatial dimensions. Crystal growth is a major stage of a crystallization process, and consists of the a ...

and

solid-state Solid state, or solid matter, is one of the four fundamental states of matter. Solid state may also refer to: Electronics * Solid-state electronics, circuits built of solid materials * Solid state ionics, study of ionic conductors and their use ...

reactivity. Ramachandran then spent two years (1947–1949) at the

Cavendish Laboratory The Cavendish Laboratory is the Department of Physics at the University of Cambridge, and is part of the School of Physical Sciences. The laboratory was opened in 1874 on the New Museums Site as a laboratory for experimental physics and is named ...

Cambridge Cambridge ( ) is a university city and the county town in Cambridgeshire, England. It is located on the River Cam approximately north of London. As of the 2021 United Kingdom census, the population of Cambridge was 145,700. Cambridge bec ...

, where he earned his PhD for 'studies on

X-ray diffuse scattering X-ray scattering techniques are a family of non-destructive analytical techniques which reveal information about the crystal structure, chemical composition, and physical properties of materials and thin films. These techniques are based on observ ...

and its application to determination of elastic constants' under the direction of Professor William Alfred Wooster, popularly known as W.A. Wooster, a leading crystallography expert in the world.

Research Works

After completing his PhD, he returned to the

in 1949 as an assistant professor of physics. In 1952, he moved to

as professor and head of the Department of Physics where he continued his work on crystal physics. His interest, however, shifted to the structure of biological

macromolecules A macromolecule is a very large molecule important to biophysical processes, such as a protein or nucleic acid. It is composed of thousands of covalently bonded atoms. Many macromolecules are polymers of smaller molecules called monomers. The ...

. Using

X-ray diffraction X-ray crystallography is the experimental science determining the atomic and molecular structure of a crystal, in which the crystalline structure causes a beam of incident X-rays to diffract into many specific directions. By measuring the angles ...

Ramachandran along with

Gopinath Kartha Gopinath Kartha (26 January 1927 – 18 June 1984) was a prominent crystallographer of Indian origin. In 1967, he determined the molecular structure of the enzyme ribonuclease. This was the first protein structure elucidated and published in ...

proposed and published the triple helical structure of

in 1954 in the journal

Nature Nature, in the broadest sense, is the physics, physical world or universe. "Nature" can refer to the phenomenon, phenomena of the physical world, and also to life in general. The study of nature is a large, if not the only, part of science. ...

, drawing worldwide scientific attention to the "Madras group". At Madras University, Professor Ramachandran was the favourite of the famous vice-chancellor and celebrated doctor and medical scientist, Sir Arcot Laksmanaswamy Mudaliar. Wanting to tackle problems at a more fundamental level, Ramachandran decided to use this information to examine the various

polypeptide Peptides (, ) are short chains of amino acids linked by peptide bonds. Long chains of amino acids are called proteins. Chains of fewer than twenty amino acids are called oligopeptides, and include dipeptides, tripeptides, and tetrapeptides. A p ...

conformations then known and also to develop a good 'yardstick' that could be used for examining and assessing any structure in general, but peptides in particular. The result which emerged from these calculations in 1962, – now commonly known as the

– was published in the

Journal of Molecular Biology The ''Journal of Molecular Biology'' is a biweekly peer-reviewed scientific journal covering all aspects of molecular biology. It was established in 1959 and is published by Elsevier. The editor-in-chief is Peter Wright ( The Scripps Research In ...

in 1963 and has become an essential tool in the field of

protein Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residues. Proteins perform a vast array of functions within organisms, including catalysing metabolic reactions, DNA replication, respo ...

conformation. When it was first calculated, crystal structures had barely been obtained for any protein. From the mid-1960s onward, Ramachandran studied many topics relating to the conformation of peptides including types of β-turns, conformation of prolyl residues, cis-peptide units, occurrence and need for non-planarity of the peptides,

NMR Nuclear magnetic resonance (NMR) is a physical phenomenon in which nuclei in a strong constant magnetic field are perturbed by a weak oscillating magnetic field (in the near field) and respond by producing an electromagnetic signal with ...

coupling constants, peptides containing L and D residues and many others. He was awarded the prestigious

Jawarharlal Nehru Fellowship The Jawaharlal Nehru Trust Scholarship U.K. was founded by Admiral Lord Mountbatten of Burma in 1966 as a tribute to the India's first Prime Minister – Jawaharlal Nehru – after his death in 1964. The scholarship was funded by the Nehru Me ...

in 1968 for research on ''Protein and Polypeptide Conformation'', he was one of its first recipients. Ramachandran can be credited for bringing together into the one field of

molecular biophysics Molecular biophysics is a rapidly evolving interdisciplinary area of research that combines concepts in physics, chemistry, engineering, mathematics and biology. It seeks to understand biomolecular systems and explain biological function in terms ...

the then disparate fields of

X-ray crystallography X-ray crystallography is the experimental science determining the atomic and molecular structure of a crystal, in which the crystalline structure causes a beam of incident X-rays to diffract into many specific directions. By measuring the angles ...

peptide synthesis In organic chemistry, peptide synthesis is the production of peptides, compounds where multiple amino acids are linked via amide bonds, also known as peptide bonds. Peptides are chemically synthesized by the condensation reaction of the carboxyl ...

, NMR and other optical studies, and physico-chemical experimentation. In 1970, he founded the Molecular Biophysics Unit at the

which was later known as the Centre of Advanced Study in Biophysics. Ramachandran and A.V. Lakshminarayanan developed convolution-backprojection algorithms which greatly improved the quality and practicality of results obtainable by x-ray tomography. Compared to previously used methods, their algorithms considerably reduced computer processing time for image reconstruction, as well as providing more numerically accurate images. As a result, commercial manufacturers of x-ray tomographic scanners started building systems capable of reconstructing high resolution images that were almost photographically perfect. In 1971, they published their research in

PNAS ''Proceedings of the National Academy of Sciences of the United States of America'' (often abbreviated ''PNAS'' or ''PNAS USA'') is a peer-reviewed multidisciplinary scientific journal. It is the official journal of the National Academy of Scien ...

. In 1981, Ramachandran became a founding member of the

World Cultural Council The World Cultural Council is an international organization whose goals are to promote cultural values, goodwill and philanthropy among individuals. The organization founded in 1981 and based in Mexico, has held a yearly award ceremony since 198 ...

. Notable awards that Ramachandran received include the

Shanti Swarup Bhatnagar Award The Shanti Swarup Bhatnagar Prize for Science and Technology (SSB) is a science award in India India, officially the Republic of India (Hindi: ), is a country in South Asia. It is the List of countries and dependencies by area, seventh-la ...

for Physics in India (1961) and the Fellowship of the

Royal Society The Royal Society, formally The Royal Society of London for Improving Natural Knowledge, is a learned society and the United Kingdom's national academy of sciences. The society fulfils a number of roles: promoting science and its benefits, re ...

of London. In 1999, the

International Union of Crystallography The International Union of Crystallography (IUCr) is an organisation devoted to the international promotion and coordination of the science of crystallography. The IUCr is a member of the International Council for Science (ICSU). Objectives ...

honoured him with the Ewald Prize for his 'outstanding contributions to crystallography'. He was nominated for the Nobel Prize as well for his fundamental contributions in protein structure and function.

Later years

Ramachandran was devastated by the death of his wife Rajalakshmi in 1998 and his health gradually deteriorated. During the last few years of his life, he suffered a stroke and was affected by

Parkinson's disease Parkinson's disease (PD), or simply Parkinson's, is a long-term degenerative disorder of the central nervous system that mainly affects the motor system. The symptoms usually emerge slowly, and as the disease worsens, non-motor symptoms becom ...

. Ramachandran died in 2001 at age 78. Leading scientists from Europe including Professor

Linus Pauling Linus Carl Pauling (; February 28, 1901August 19, 1994) was an American chemist, biochemist, chemical engineer, peace activist, author, and educator. He published more than 1,200 papers and books, of which about 850 dealt with scientific top ...

and Professor

Francis Crick Francis Harry Compton Crick (8 June 1916 – 28 July 2004) was an English molecular biologist, biophysicist, and neuroscientist. He, James Watson, Rosalind Franklin, and Maurice Wilkins played crucial roles in deciphering the helical struc ...

regarded Professor Ramchandran as a Nobel Prize calibre scientist of great reputation.

Legacy

Each year, the

Council of Scientific and Industrial Research The Council of Scientific and Industrial Research (IAST: ''vaigyanik tathā audyogik anusandhāna pariṣada''), abbreviated as CSIR, was established by the Government of India in September 1942 as an autonomous body that has emerged as the l ...

(CSIR) awards the "G N Ramachandran Gold Medal for Excellence in Biological Sciences & Technology" in his memory for work in Biological Sciences & Technology.

References

External links