The Conserved oligomeric Golgi complex (COG) is a multi

protein complex A protein complex or multiprotein complex is a group of two or more associated polypeptide chains. Protein complexes are distinct from multienzyme complexes, in which multiple catalytic domains are found in a single polypeptide chain. Protein c ...

found in the

Golgi apparatus The Golgi apparatus (), also known as the Golgi complex, Golgi body, or simply the Golgi, is an organelle found in most eukaryotic cells. Part of the endomembrane system in the cytoplasm, it packages proteins into membrane-bound vesicles ins ...

structure and involved in

intracellular transport Intracellular transport is the movement of vesicles and substances within a cell. Intracellular transport is required for maintaining homeostasis within the cell by responding to physiological signals. Proteins synthesized in the cytosol are dist ...

and glycoprotein modification. Earlier names for this complex were : the Golgi transport complex (GTC), the LDLC complex, which is involved in glycosylation reactions, and the SEC34 complex, which is involved in vesicular transport. These 3 complexes are identical and have been termed the conserved oligomeric Golgi (COG) complex (Ungar et al., 2002). upplied by OMIMref name="entrez"> ;Structure: The COG protein complex consists of eight subunits, in two lobes; Lobe A consists of

COG1 Conserved oligomeric Golgi complex subunit 1 is a protein that in humans is encoded by the ''COG1'' gene. The protein encoded by this gene is one of eight proteins (Cog1-8) which form a Golgi-localized complex (COG) required for normal Golgi morp ...

COG2 Conserved oligomeric Golgi complex subunit 2 is a protein that in humans is encoded by the ''COG2'' gene. Multiprotein complexes are key determinants of Golgi apparatus structure and its capacity for intracellular transport and glycoprotein modifi ...

COG3 Conserved oligomeric Golgi complex subunit 3 is a protein that in humans is encoded by the ''COG3'' gene. The protein encoded by this gene has similarity to a yeast protein. It seems to be part of a peripheral membrane protein complex localized o ...

COG4 Conserved oligomeric Golgi complex subunit 4 is a protein that in humans is encoded by the ''COG4'' gene. Multiprotein complexes are key determinants of Golgi apparatus structure and its capacity for intracellular transport and glycoprotein modif ...

and lobe B consists of

COG5 Conserved oligomeric Golgi complex subunit 5 is a protein that in humans is encoded by the ''COG5'' gene. Multiprotein complexes are key determinants of Golgi apparatus structure and its capacity for intracellular transport and glycoprotein modif ...

, COG6,

COG7 Conserved oligomeric Golgi complex subunit 7 is a protein that in humans is encoded by the ''COG7'' gene. Multiprotein complexes are key determinants of Golgi apparatus structure and its capacity for intracellular transport and glycoprotein modi ...

, COG8.

Function

The conserved oligomeric Golgi complex plays important roles in maintaining the structure and transport mechanisms within the Golgi apparatus.

References

Protein complexes {{protein-stub

Function

Further reading

References