Beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase (, ''N-acetylglucosaminyltransferase III'', ''N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase III'', ''uridine diphosphoacetylglucosamine-glycopeptide beta4-acetylglucosaminyltransferase III'', ''beta-1,4-mannosyl-glycoprotein beta-1,4-N-acetylglucosaminyltransferase'', ''GnTIII'') is an
enzyme
Enzymes () are proteins that act as biological catalysts by accelerating chemical reactions. The molecules upon which enzymes may act are called substrates, and the enzyme converts the substrates into different molecules known as products. A ...
with
systematic name A systematic name is a name given in a systematic way to one unique group, organism, object or chemical substance, out of a specific population or collection. Systematic names are usually part of a nomenclature.
A semisystematic name or semitrivial ...
''UDP-N-acetyl-D-glucosamine:beta-D-mannosyl-glycoprotein 4-beta-N-acetyl-D-glucosaminyltransferase''.
This enzyme
catalyses the following
chemical reaction
A chemical reaction is a process that leads to the IUPAC nomenclature for organic transformations, chemical transformation of one set of chemical substances to another. Classically, chemical reactions encompass changes that only involve the pos ...
:
UDP-N-acetyl-D-glucosamine + beta-D-mannosyl-R
UDP + 4-(N-acetyl-beta-D-glucosaminyl)-beta-D-mannosyl-R
R represents the remainder of the N-linked
oligosaccharide
An oligosaccharide (/ˌɑlɪgoʊˈsækəˌɹaɪd/; from the Greek ὀλίγος ''olígos'', "a few", and σάκχαρ ''sácchar'', "sugar") is a saccharide polymer containing a small number (typically two to ten) of monosaccharides (simple sugar ...
in the
glycoprotein
Glycoproteins are proteins which contain oligosaccharide chains covalently attached to amino acid side-chains. The carbohydrate is attached to the protein in a cotranslational or posttranslational modification. This process is known as glycos ...
acceptor.
References
External links
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EC 2.4.1