In molecular biology, Glycoside hydrolase family 17 is a
family
Family (from la, familia) is a Social group, group of people related either by consanguinity (by recognized birth) or Affinity (law), affinity (by marriage or other relationship). The purpose of the family is to maintain the well-being of its ...
of
glycoside hydrolase
Glycoside hydrolases (also called glycosidases or glycosyl hydrolases) catalyze the hydrolysis of glycosidic bonds in complex sugars. They are extremely common enzymes with roles in nature including degradation of biomass such as cellulose (cel ...
s. It folds into a
TIM barrel
The TIM barrel (triose-phosphate isomerase), also known as an alpha/beta barrel, is a conserved protein fold consisting of eight alpha helices (α-helices) and eight parallel beta strands (β-strands) that alternate along the peptide backbone. ...
.
Glycoside hydrolases are a widespread group of enzymes that
hydrolyse
Hydrolysis (; ) is any chemical reaction in which a molecule of water breaks one or more chemical bonds. The term is used broadly for substitution, elimination, and solvation reactions in which water is the nucleophile.
Biological hydrolysis ...
the
glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety. A classification system for glycoside hydrolases, based on sequence similarity, has led to the definition of >100 different families.
This classification is available on the
CAZy web site, and also discussed at CAZypedia, an online encyclopedia of carbohydrate active enzymes.
y
_
Glycoside hydrolase family 1
CAZY GH_17comprises enzymes with several known activities; endo-1,3-beta-glucosidase (); lichenase (); exo-1,3-glucanase (). Currently these enzymes have only been found in plants and in fungi.
References
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EC 3.2.1
GH family
Protein families