Sodium- and chloride-dependent glycine transporter 1, also known as glycine transporter 1, is a

protein Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residues. Proteins perform a vast array of functions within organisms, including catalysing metabolic reactions, DNA replication, res ...

that in humans is encoded by the ''SLC6A9''

gene In biology, the word gene (from , ; "... Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ''birth'' or ''gender'') can have several different meanings. The Mendelian gene is a b ...

Selective inhibitors

Elevation of extracellular synaptic

glycine Glycine (symbol Gly or G; ) is an amino acid that has a single hydrogen atom as its side chain. It is the simplest stable amino acid ( carbamic acid is unstable), with the chemical formula NH2‐ CH2‐ COOH. Glycine is one of the proteinog ...

concentration by blockade of GlyT1 has been hypothesized to potentiate NMDA receptor function in vivo and to represent a rational approach for the treatment of

schizophrenia Schizophrenia is a mental disorder characterized by continuous or relapsing episodes of psychosis. Major symptoms include hallucinations (typically hearing voices), delusions, and disorganized thinking. Other symptoms include social wit ...

and cognitive disorders. Several drug candidates have reached clinical trials. *

ASP2535 Asp may refer to: Places * Asp, part of Densbüren, Aargau, Switzerland * Aspe (''Asp'' in Valencian), Alicante, Spain * Asp Lake, a lake in Minnesota Animals * Asp (fish) * Asp (snake), in antiquity, one of several venomous snakes ** '' C ...

Bitopertin Bitopertin (developmental code names RG1678; RO-4917838) is a glycine reuptake inhibitor which was under development by Roche as an adjunct to antipsychotics for the treatment of persistent negative symptoms or suboptimally controlled positive ...

(RG1678), which has entered phase II trials for the treatment of schizophrenia * Iclepertin (

BI 425809 Iclepertin (BI 425809) is an investigational nootropic to enhance the cognition and functional capacity in schizophrenia developed by Boehringer Ingelheim. As of May 2020, it is in phase III of clinical trial under the code name CONNEX-3. BI 425809 ...

) by Boehringer Ingelheim which is thought to improve cognitive impairment due to schizophrenia *

Org 25935 ORG-25935, also known as SCH-900435 is a synthetic drug developed by Organon International, which acts as a selective inhibitor of the glycine transporter GlyT-1. In animal tests it reduces alcohol consumption and has analgesic and anticonvulsan ...

(Sch 900435) * PF-03463275 (in phase II trial) *

Pesampator Pesampator (; developmental code names BIIB-104 and PF-04958242) is a positive allosteric modulator (PAM) of the AMPA receptor (AMPAR), an ionotropic glutamate receptor, which is under development by Pfizer for the treatment of cognitive sympto ...

(PF-04958242) by Pfizer *

Sarcosine Sarcosine, also known as ''N''-methylglycine, or monomethylglycine, is a monopeptide with the formula CH3N(H)CH2CO2H. It exists at neutral pH as the zwitterion CH3N+(H)2CH2CO2−, which can be obtained as a white, water-soluble powder. Like som ...

which is thought to improve cognitive impairment due to schizophrenia

Selective inhibitors

See also

References

Further reading