In molecular biology, the glucose-methanol-choline oxidoreductase family (GMC oxidoreductase) is a family of

enzymes Enzymes () are proteins that act as biological catalysts by accelerating chemical reactions. The molecules upon which enzymes may act are called substrate (chemistry), substrates, and the enzyme converts the substrates into different molecule ...

with

oxidoreductase In biochemistry, an oxidoreductase is an enzyme that catalyzes the transfer of electrons from one molecule, the reductant, also called the electron donor, to another, the oxidant, also called the electron acceptor. This group of enzymes usually ut ...

activity. The glucose-methanol-choline (GMC) oxidoreductases are

FAD A fad or trend is any form of collective behavior that develops within a culture, a generation or social group in which a group of people enthusiastically follow an impulse for a short period. Fads are objects or behaviors that achieve short- ...

flavoproteins Flavoproteins are proteins that contain a nucleic acid derivative of riboflavin. Flavoproteins are involved in a wide array of biological processes, including removal of radicals contributing to oxidative stress, photosynthesis, and DNA repair. ...

oxidoreductases. These enzymes include a variety of proteins;

choline dehydrogenase In enzymology, a choline dehydrogenase () is an enzyme that catalyzes the chemical reaction :choline + acceptor \rightleftharpoons betaine aldehyde + reduced acceptor Thus, the two substrates of this enzyme are choline and acceptor, whereas i ...

(CHD) , methanol oxidase (MOX) and cellobiose dehydrogenase which share a number of regions of

sequence In mathematics, a sequence is an enumerated collection of objects in which repetitions are allowed and order matters. Like a set, it contains members (also called ''elements'', or ''terms''). The number of elements (possibly infinite) is calle ...

similarities. They contain two conserved

protein domains In molecular biology, a protein domain is a region of a protein's polypeptide chain that is self-stabilizing and that folds independently from the rest. Each domain forms a compact folded three-dimensional structure. Many proteins consist of s ...

. The

N-terminal The N-terminus (also known as the amino-terminus, NH2-terminus, N-terminal end or amine-terminus) is the start of a protein or polypeptide, referring to the free amine group (-NH2) located at the end of a polypeptide. Within a peptide, the ami ...

domain corresponds to the FAD ADP-binding domain, the C-terminal domain is a steroid-binding domain.

References

{{Alcohol oxidoreductases Protein domains