The enzyme Glucosaminate ammonia-lyase (EC 4.3.1.9)

catalyzes Catalysis () is the process of increasing the rate of a chemical reaction by adding a substance known as a catalyst (). Catalysts are not consumed in the reaction and remain unchanged after it. If the reaction is rapid and the catalyst recyc ...

the chemical reaction :2-amino-2-deoxy-D-gluconate = 2-dehydro-3-deoxy-D-gluconate + NH₃ (overall reaction) ::(1a) 2-amino-2-deoxy-Dgluconate = (2''Z'',4''S'',5''R'')-2-amino-4,5,6-trihydroxyhex-2-enoate + H₂O ::(1b) (2''Z'',4''S'',5''R'')-2-amino-4,5,6-trihydroxyhex-2-enoate = (4''S'',5''R'')-4,5,6-trihydroxy-2-iminohexanoate (spontaneous) ::(1c) (4''S'',5''R'')-4,5,6-trihydroxy-2-iminohexanoate + H₂O = 2-dehydro-3-deoxyD-gluconate + NH₃ (spontaneous) This enzyme belongs to the family of

lyase In biochemistry, a lyase is an enzyme that catalyzes the breaking (an elimination reaction) of various chemical bonds by means other than hydrolysis (a substitution reaction) and oxidation, often forming a new double bond or a new ring structure. ...

s, specifically ammonia lyases, which cleave carbon-nitrogen bonds. The systematic name of this enzyme class is 2-amino-2-deoxy-D-gluconate ammonia-lyase (isomerizing; 2-dehydro-3-deoxy-D-gluconate-forming). Other names in common use include glucosaminic dehydrase, D-glucosaminate dehydratase, D-glucosaminic acid dehydrase, aminodeoxygluconate dehydratase, 2-amino-2-deoxy-D-gluconate hydro-lyase (deaminating), aminodeoxygluconate ammonia-lyase, 2-amino-2-deoxy-D-gluconate ammonia-lyase, and D-glucosaminate ammonia-lyase. This enzyme participates in the pentose phosphate pathway. It employs one cofactor, pyridoxal phosphate.

References

* * * * EC 4.3.1 Pyridoxal phosphate enzymes Enzymes of unknown structure {{enzyme-stub