Glenda Gobe is a molecular biologist specialising in the molecular controls of

apoptosis Apoptosis (from grc, ἀπόπτωσις, apóptōsis, 'falling off') is a form of programmed cell death that occurs in multicellular organisms. Biochemical events lead to characteristic cell changes (morphology) and death. These changes incl ...

in kidney disease. She is Co-Director of the Centre for Kidney Disease Research (CKDR), School of Medicine, Translational Research Institute and

The University of Queensland , mottoeng = By means of knowledge and hard work , established = , endowment = A$224.3 million , budget = A$2.1 billion , type = Public research university , chancellor = Peter Varghese , vice_chancellor = Deborah Terry , city = Br ...

and Reader in the Discipline of Medicine at the School of Medicine, University of Queensland.

Biography

Associate Professor Gobe is a molecular biologist with a well-established international record of achievements in

kidney disease Kidney disease, or renal disease, technically referred to as nephropathy, is damage to or disease of a kidney. Nephritis is an inflammatory kidney disease and has several types according to the location of the inflammation. Inflammation can ...

research. She produced the first study, internationally, on the role of apoptosis in kidney disease.

Education

Gobe completed her studies at the University of Queensland. Her studies included a Bachelor of Science, a Graduate Diploma of Education, and a Masters of Science. She completed her PhD with Professors Roy Axelsen (analgesic nephropathy) and John Kerr (

) and received overseas post-doctoral training from the College of Physicians and Surgeons,

Columbia University Columbia University (also known as Columbia, and officially as Columbia University in the City of New York) is a private research university in New York City. Established in 1754 as King's College on the grounds of Trinity Church in Manhatt ...

with Prof Ralph Buttyan, one of the leading world experts in the molecular biology of apoptosis and specialising in prostate cancer research.

Research

Gobe has extensive expertise in research into renal atrophy and regeneration,

fibrosis Fibrosis, also known as fibrotic scarring, is a pathological wound healing in which connective tissue replaces normal parenchymal tissue to the extent that it goes unchecked, leading to considerable tissue remodelling and the formation of perma ...

, immunity and

inflammation Inflammation (from la, wikt:en:inflammatio#Latin, inflammatio) is part of the complex biological response of body tissues to harmful stimuli, such as pathogens, damaged cells, or Irritation, irritants, and is a protective response involving im ...

, and kidney cancer. She has designed in vitro and in vivo pre-clinical models to test hypotheses on the pathogenesis of kidney and other tissue disease, and promotes the translation of results to the clinic. She has promoted the understanding the role of apoptosis in

cancer Cancer is a group of diseases involving abnormal cell growth with the potential to invade or spread to other parts of the body. These contrast with benign tumors, which do not spread. Possible signs and symptoms include a lump, abnormal b ...

biology and general disease, and played an integral role in defining and characterising the role of apoptosis in kidney disease. Her current research focus is on the modulation of oxidative stress and mitochondrial dysfunction in renal disease, including renal cancer; and a systems biology approach to study chronic kidney disease.

References

External links

University of Queensland, School of Medicine staff profile

University of Queensland, Researchers profile

Translational Research Institute staff profile
{{DEFAULTSORT:Gobe, Glenda Australian women scientists Living people Year of birth missing (living people) Australian molecular biologists University of Queensland alumni Academic staff of the University of Queensland