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Given Imaging (
Hebrew Hebrew (; ; ) is a Northwest Semitic language of the Afroasiatic language family. Historically, it is one of the spoken languages of the Israelites and their longest-surviving descendants, the Jews and Samaritans. It was largely preserved ...
: גיוון אימג'ינג) is an Israeli
medical technology Health technology is defined by the World Health Organization as the "application of organized knowledge and skills in the form of devices, medicines, vaccines, procedures, and systems developed to solve a health problem and improve quality of liv ...
company that manufactures and markets diagnostic products for the visualization and detection of disorders of the
gastrointestinal tract The gastrointestinal tract (GI tract, digestive tract, alimentary canal) is the tract or passageway of the digestive system that leads from the mouth to the anus. The GI tract contains all the major organ (biology), organs of the digestive syste ...
. Until March 2014, it was dual-listed on both the
NASDAQ The Nasdaq Stock Market () (National Association of Securities Dealers Automated Quotations Stock Market) is an American stock exchange based in New York City. It is the most active stock trading venue in the US by volume, and ranked second ...
and the
Tel Aviv Stock Exchange The Tel Aviv Stock Exchange (TASE; ; colloquially known as The Bursa, ) is Israel's only public stock exchange and a public company that has been traded on the Tel-Aviv Stock Exchange since August 1, 2019. Legally, the exchange is regulated by ...
, where it was a component of the
TA-100 Index The TA-125 Index, typically referred to as the Tel Aviv 125 and formerly the TA-100 Index, is a stock market index of the 125 most highly capitalised companies listed on the Tel Aviv Stock Exchange (TASE). The index began on 1 January 1992 with ...
and the
TA BlueTech Index The TA BlueTech Index is a stock market index all capitalised information technology and biotechnology companies listed on the Tel Aviv Stock Exchange (TASE). The index was launched on 3 April 2011 as the TA BlueTech-50 Index and replaced by the ...
. In March 2014 it was acquired by
Covidien Covidien was an Irish-headquartered global health care products company and manufacturer of medical devices and supplies. Covidien became an independent publicly traded company after being spun off from Tyco International in 2007. It was purcha ...
and became a private company. In 2015
Covidien Covidien was an Irish-headquartered global health care products company and manufacturer of medical devices and supplies. Covidien became an independent publicly traded company after being spun off from Tyco International in 2007. It was purcha ...
was purchased by
Medtronic Medtronic plc is an American medical device company. The company's operational and executive headquarters are in Minneapolis, Minnesota, and its legal headquarters are in Ireland due to its acquisition of Irish-based Covidien in 2015. While it ...
. Given Imaging pioneered the
capsule endoscopy Capsule endoscopy is a medical procedure used to record internal images of the gastrointestinal tract for use in disease diagnosis. Newer developments are also able to take biopsies and release medication at specific locations of the entire ...
technology and has also developed capsule-based pH monitoring. Through Sierra Scientific Instruments, a subsidiary, Given Imaging also provides an array of diagnostic modalities including high-resolution manometry and ambulatory reflux monitoring. Given Imaging's technology is currently marketed in over 60 countries.


History

Given Imaging was founded in 1998 by Gavriel Meron and Rafael Development Corporation (RDC) Ltd. based on the purchase of an early patent from Rafael Advanced Defense Systems Ltd. Initial funding for the company was provided by
Elron Electronic Industries Elron Electronic Industries is an Israeli technology holding company based in Tel Aviv; since 1962 the company has been involved in setting up, funding and developing over 30 companies and is considered one of the foundation stones of the high-t ...
, Israel's leading technology holding company, in cooperation with Rafael. Today, Elron still holds 28% Given Imaging's shares. The idea for the solution was developed by Dr. Iddan, while working in the missile division of Rafael, where he envisioned that missile technology could be miniaturized to create a medical product. The company's first
capsule endoscopy Capsule endoscopy is a medical procedure used to record internal images of the gastrointestinal tract for use in disease diagnosis. Newer developments are also able to take biopsies and release medication at specific locations of the entire ...
products was named M2A capsule and received it
CE marking On commercial products, the letters CE (as the logo ) mean that the manufacturer or importer affirms the good's conformity with European health, safety, and environmental protection standards. It is not a quality indicator or a certificatio ...
in May 2001 and in August 2001 was cleared by the
US Food and Drug Administration The United States Food and Drug Administration (FDA or US FDA) is a federal agency of the Department of Health and Human Services. The FDA is responsible for protecting and promoting public health through the control and supervision of food s ...
(FDA) for visualization of abnormalities of the small intestine The capsule uses a radio developed for Given by Zarlink Semiconductor's medical team in San Diego and Jarfalla, Sweden. In October 2001, Given Imaging had an
Initial public offering An initial public offering (IPO) or stock launch is a public offering in which shares of a company are sold to institutional investors and usually also to retail (individual) investors. An IPO is typically underwritten by one or more investment ...
on
NASDAQ The Nasdaq Stock Market () (National Association of Securities Dealers Automated Quotations Stock Market) is an American stock exchange based in New York City. It is the most active stock trading venue in the US by volume, and ranked second ...
under ticker GIVN.) In September 2004, M2A capsule re-branded PillCam SB(R). In March 2004, Given Imaging became a member of the
Tel Aviv Stock Exchange The Tel Aviv Stock Exchange (TASE; ; colloquially known as The Bursa, ) is Israel's only public stock exchange and a public company that has been traded on the Tel-Aviv Stock Exchange since August 1, 2019. Legally, the exchange is regulated by ...
In November 2004, US FDA clears PillCam(R) ESO for the esophagus In May 2006, US FDA clears Agile Patency System In October 2006, PillCam COLON was cleared for marketing in the European Union (CE Mark) In December 2008, Given Imaging acquired Bravo pH Monitoring System(R) In May 2009, 1 millionth PillCam capsule was sold In September 2009, PillCam COLON 2 receives CE Mark In July 2012, Given Imaging's
capsule endoscopy Capsule endoscopy is a medical procedure used to record internal images of the gastrointestinal tract for use in disease diagnosis. Newer developments are also able to take biopsies and release medication at specific locations of the entire ...
featured in a live broadcast on the
BBC #REDIRECT BBC #REDIRECT BBC Here i going to introduce about the best teacher of my life b BALAJI sir. He is the precious gift that I got befor 2yrs . How has helped and thought all the concept and made my success in the 10th board exam. ...
...
, when the reporter Michael Mosley spent the day as an exhibit at
the Science Museum The Science Museum is a major museum on Exhibition Road in South Kensington, London. It was founded in 1857 and is one of the city's major tourist attractions, attracting 3.3 million visitors annually in 2019. Like other publicly funded ...
in London, after swallowing a PillCam which transmitted live pictures to a public screen. In February 2014, 100% of Given Imaging's shares were purchased by
Covidien Covidien was an Irish-headquartered global health care products company and manufacturer of medical devices and supplies. Covidien became an independent publicly traded company after being spun off from Tyco International in 2007. It was purcha ...
, making it a
Private Company A privately held company (or simply a private company) is a company whose shares and related rights or obligations are not offered for public subscription or publicly negotiated in the respective listed markets, but rather the company's stock is ...
fully owned by Covidien. As a result, its shares are no longer traded neither in NASDAQ nor in TASE In 2015
Covidien Covidien was an Irish-headquartered global health care products company and manufacturer of medical devices and supplies. Covidien became an independent publicly traded company after being spun off from Tyco International in 2007. It was purcha ...
was purchased by
Medtronic Medtronic plc is an American medical device company. The company's operational and executive headquarters are in Minneapolis, Minnesota, and its legal headquarters are in Ireland due to its acquisition of Irish-based Covidien in 2015. While it ...


Products


PillCam SB

PillCam SB is a patient-friendly tool for visualization of the entire small bowel and detection of small bowel abnormalities. No sedation is needed, however bowel prep is needed. A liquid bowel prep is consumed before the procedure emptying the bowel completely, this allows clear photos to be taken.


PillCam ESO

PillCam ESO provides a clinically proven, time-efficient and patient-friendly method for visualization of the esophagus.


PillCam COLON 2

PillCam COLON 2 is complementary to traditional colonoscopy and is used for patients who have received incomplete colonoscopy, are contraindicated for colonoscopy or are unwilling to undergo traditional colonoscopy.


PillCam CROHN'S

The PillCam CROHN’S system offers a solution by obtaining direct visualization of the entire small bowel and colonic mucosa with a noninvasive procedure.


PillCam Express

In May 2010, Given Imaging released a new manually guided GI scope based on PillCam swallowable devices. In cases where patient anatomy does not allow for natural passage of large tablets the size of traditional PillCams, the PillCam Express can be delivered through the stomach and into the small intestine with help of an endoscope and a proprietary balloon deployment mechanism.


Bravo pH Monitoring System

The Bravo pH Monitoring System is a catheter-free ambulatory pH test. Ambulatory pH testing is considered the gold standard for pH measurement and monitoring of gastric reflux, helping clinicians manage gastroesophageal reflux disease (GERD). Featuring data collection for up to 96 hours, Bravo allows patients to maintain their regular diets and activities, accurately reflecting normal physiologic conditions.


Sierra Scientific Instruments

In April 2010, Given Imaging acquired Sierra Scientific Instruments, a leading provider of specialty GI diagnostic solutions and pioneer of high-resolution manometry for assessing gastrointestinal motility. The ManoScan 360 High-Resolution Manometry System has advanced diagnostic technology that captures all relevant esophageal motor function from the pharynx to the stomach with a single placement of the catheter. An average esophageal study can be completed in 10 minutes or less. The ManoScan 360 can be upgraded to incorporate an array of diagnostic modalities including manometry with impedance as well as anorectal and 3D HRM Manometry. Sierra Scientific also provides the AccuTrac pH and pH-Impedance Monitoring System, pH and pH-Z disposable catheters and ManoShield disposable catheter sheaths for both esophageal and anorectal catheters. Additionally, Sierra Scientific offers the Polygraf ID stationary gastrointestinal function testing platform and the Digitrapper(R) ambulatory pH monitoring system.


Headquarters and plants

The company's corporate headquarters, research and development laboratories, and manufacturing facilities are located in Yokneam, Israel.
GIVEN IMAGING LTD , Israel Company Search
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It maintains offices in
Duluth, Georgia Duluth is a city in Gwinnett County, Georgia, Gwinnett County, Georgia (U.S. state), Georgia, United States. Located north of Interstate 85, it is approximately northeast of Atlanta. As of the 2020 United States Census, 2020 census, Duluth had a ...
and
Heerlen Heerlen (; li, Heële ) is a city and a municipality in the southeast of the Netherlands. It is the third largest settlement proper in the province of Limburg. Measured as municipality, it is the fourth municipality in the province of Limburg. ...
,
Netherlands ) , anthem = ( en, "William of Nassau") , image_map = , map_caption = , subdivision_type = Sovereign state , subdivision_name = Kingdom of the Netherlands , established_title = Before independence , established_date = Spanish Netherl ...
. Additional sales and marketing offices are located in
France France (), officially the French Republic ( ), is a country primarily located in Western Europe. It also comprises of Overseas France, overseas regions and territories in the Americas and the Atlantic Ocean, Atlantic, Pacific Ocean, Pac ...
,
Japan Japan ( ja, 日本, or , and formally , ''Nihonkoku'') is an island country in East Asia. It is situated in the northwest Pacific Ocean, and is bordered on the west by the Sea of Japan, while extending from the Sea of Okhotsk in the north ...
,
Australia Australia, officially the Commonwealth of Australia, is a Sovereign state, sovereign country comprising the mainland of the Australia (continent), Australian continent, the island of Tasmania, and numerous List of islands of Australia, sma ...
, and
Singapore Singapore (), officially the Republic of Singapore, is a sovereign island country and city-state in maritime Southeast Asia. It lies about one degree of latitude () north of the equator, off the southern tip of the Malay Peninsula, borde ...
. The company also has a plant in
Ireland Ireland ( ; ga, Éire ; Ulster Scots dialect, Ulster-Scots: ) is an island in the Atlantic Ocean, North Atlantic Ocean, in Northwestern Europe, north-western Europe. It is separated from Great Britain to its east by the North Channel (Grea ...
. Given Imaging's wholly owned subsidiary, Sierra Scientific Instruments, is located in
Los Angeles Los Angeles ( ; es, Los Ángeles, link=no , ), often referred to by its initials L.A., is the largest city in the state of California and the second most populous city in the United States after New York City, as well as one of the world' ...
, California, with manufacturing operations in Vietnam.


See also

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Science and technology in Israel Science and technology in Israel is one of the country's most developed sectors. Israel spent 4.3% of its gross domestic product (GDP) on civil research and development in 2015, the highest ratio in the world. In 2019, Israel was ranked the world' ...
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Health care in Israel Healthcare in Israel is universal and participation in a medical insurance plan is compulsory. All Israeli residents are entitled to basic health care as a fundamental right. The Israeli healthcare system is based on the National Health Insurance ...
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List of Israeli inventions and discoveries This is a list of inventions and discoveries by Israeli scientists and researchers, working locally or overseas. There are over 6,000 startups currently in Israel. There are currently more than 30 technology companies valued over US$1 billion (un ...
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Silicon Wadi Silicon Wadi ( he, סִילִיקוֹן וְאֵדֵי, ) is a region in Israel that serves as one of the global centres for advanced technology. It spans the Israeli coastal plain, and is cited as among the reasons why the country has b ...
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Startup Village, Yokneam Yokneam Illit ( he, יָקְנְעָם עילית), also ''Yoqne'am Illit'' and ''Jokneam Illit'', is a city in northern Israel. It is located in a hilly region of the lower Galilee at the base of the Carmel Mountains, and overlooks the Jezreel V ...


References

{{Israel NASDAQ Gastroenterology Optics manufacturing companies Medical technology companies of Israel Companies formerly listed on the Nasdaq Companies established in 1998 Israeli inventions