Giuffre or Giuffrè is a surname. Notable people with the surname include: * Aldo Giuffrè (1924–2010), Italian film actor and comedian who appeared in over 90 films * Antonino Giuffrè (born 1945), Italian former mafioso from Caccamo, Palermo, Sicily * Carlo Giuffrè (1928–2018), Italian film actor * Gaetano Giuffrè (1918–2018), Italian-Greek composer * Jimmy Giuffre (1921–2008), American jazz composer, arranger, saxophone and clarinet player * Matthew Giuffre (born 1982), Canadian squash player * Virginia Giuffre (1983–2025), an American-Australian woman who accused Jeffrey Epstein and his associates of rape

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