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Georgeanna Seegar Jones (July 6, 1912 – March 26, 2005) was an American reproductive endocrinologist who with her husband,
Howard W. Jones Howard Wilbur Jones, Jr. (December 30, 1910 – July 31, 2015) was an American gynecological surgeon and in vitro fertilization (IVF) specialist. Jones and his wife, Georgeanna Seegar Jones, were two of the earliest reproductive medicine speciali ...
, pioneered
in vitro fertilization In vitro fertilisation (IVF) is a process of fertilisation where an egg is combined with sperm in vitro ("in glass"). The process involves monitoring and stimulating an individual's ovulatory process, removing an ovum or ova (egg or eggs) ...
in the United States.


Early life

She was born July 6, 1912, in
Baltimore, Maryland Baltimore ( , locally: or ) is the List of municipalities in Maryland, most populous city in the U.S. state of Maryland, fourth most populous city in the Mid-Atlantic (United States), Mid-Atlantic, and List of United States cities by popula ...
, to J. King Seegar. Her father was a obstetrician, one of the many things that led to Seegar Jones's interest in medicine from a young age. She was raised along with two siblings. She received her bachelor's degree in 1932 from Goucher College and continued to pursue her medical career at Johns Hopkins University School of Medicine. Four years later, 1936, she got her official medical degree (MD). She completed her training as a house gynecology officer and an acting member of the National Cancer Institute. While attending medical school she met her husband, Howard W. Jones, Jr., whom she married in 1940. Reproductive endocrinology was not yet a subspecialty, in fact, her and her husband's accomplishments have contributed to the successful reproductive endocrinology programs that are offered at Johns Hopkins.


Career

As a resident at Johns Hopkins, she discovered that the common pregnancy hormone, human chorionic gonadotropin, hCG was produced by the
placenta The placenta is a temporary embryonic and later fetal organ that begins developing from the blastocyst shortly after implantation. It plays critical roles in facilitating nutrient, gas and waste exchange between the physically separate mater ...
, not the
pituitary gland In vertebrate anatomy, the pituitary gland, or hypophysis, is an endocrine gland, about the size of a chickpea and weighing, on average, in humans. It is a protrusion off the bottom of the hypothalamus at the base of the brain. The ...
as originally thought. Thus leading to the development of the hCG pregnancy test that are currently on the market. By the late 1940's Jones had a copious amount of experience with studying infertility in couples, using endocrinological techniques. At this time, there was no substantial research on endocrinology and the link to infertility so Jones submitted an article of her findings to the American Medical Association titled "Some Newer Aspects of the Management of Infertility". Within this article was the advancements she has made studying the luteal phase defect, a term which Jones is responsible for. In 1949, Jones made the first description of Luteal Phase Dysfunction and is credited to be the first in using
progesterone Progesterone (P4) is an endogenous steroid and progestogen sex hormone involved in the menstrual cycle, pregnancy, and embryogenesis of humans and other species. It belongs to a group of steroid hormones called the progestogens and is the m ...
to treat women with a history of
miscarriages Miscarriage, also known in medical terms as a spontaneous abortion and pregnancy loss, is the death of an embryo or fetus before it is able to survive independently. Miscarriage before 6 weeks of gestation is defined by ESHRE as biochemical lo ...
, thus allowing many of them to not only conceive, but to deliver healthy babies. The pregnanediol technique was developed by Jones along with other Hopkins members. Conclusions drawn from her individual research showed that low progesterone levels lead to low preganediol levels and provide a greater risk for infertility. She became the director of Johns Hopkins' Laboratory of Reproductive Physiology and was the Gynecologist-in-Charge of the hospital's gynecologic endocrinology clinic in 1939. She married
Howard W. Jones Howard Wilbur Jones, Jr. (December 30, 1910 – July 31, 2015) was an American gynecological surgeon and in vitro fertilization (IVF) specialist. Jones and his wife, Georgeanna Seegar Jones, were two of the earliest reproductive medicine speciali ...
while at Johns Hopkins and they had three children.


Later life

In 1969, Seegar Jones began to identify and examine what is now known as ovarian resistance syndrome. She demonstrated that stimulation of menopausal gonadotropin leads to the increase in number of eggs that are available and viable for vitro fertilization. In 1978, the same year that UK scientists were successful with in vitro fertilization, the Joneses took an opportunity from EVMS and moved to Norfolk, Virginia to create an IVF program in the United States. This was after the birth of the first
test tube baby In vitro fertilisation (IVF) is a process of fertilisation where an ovum, egg is combined with spermatozoon, sperm in vitro ("in glass"). The process involves monitoring and stimulating an individual's Ovulation cycle, ovulatory process, remo ...
in the world,
Louise Joy Brown Louise Joy Brown (born 25 July 1978) is an English woman who was the first human to have been born after conception by ''in vitro'' fertilisation experiment (IVF). Her birth, following a procedure pioneered in Britain, has been lauded among "t ...
, on July 25, 1978, in England. The Joneses created their own IVF program at EVMS. On December 28, 1981, their procedure gave birth to
Elizabeth Jordan Carr Elizabeth Jordan Carr (born December 28, 1981 at 7:46 am) is the United States' first baby born from the in-vitro fertilization procedure and the 15th in the world. The technique was conducted at Eastern Virginia Medical School in Norfolk under t ...
, the first American
test tube baby In vitro fertilisation (IVF) is a process of fertilisation where an ovum, egg is combined with spermatozoon, sperm in vitro ("in glass"). The process involves monitoring and stimulating an individual's Ovulation cycle, ovulatory process, remo ...
. Jones died on March 26, 2005, in
Portsmouth, Virginia Portsmouth is an independent city in southeast Virginia and across the Elizabeth River from Norfolk. As of the 2020 census, the population was 97,915. It is part of the Hampton Roads metropolitan area. The Norfolk Naval Shipyard and Naval M ...
.


Awards

Dr. Seegar Jones was awarded the Distinguished Service Award Medal from the Cosmopolitan Club of Norfolk in 1988 for the advancements she made to in vitro fertilization. She is also a recipient of the Dean's Outstanding Faculty Award from Eastern Virginia Medical School, 1996; and in 1997, the Distinguished Alumnus Award from Johns Hopkins University, also for her contributions to reproductive endocrinology and success she made with IVF. Five years prior to her passing, 2000, she received the Distinguished Scientist Award from the Gynecologic Investigation. She was one of the first in her field to train medical students, residents and fellows for several schools. Her dedication to bettering the physician generations below her paved the way of academic medicine. One of the many reason why Dr. Seegar Jones is so distinguished and honored in her field. She was named the first woman President of the American Fertility Society in 1970. One of the reasons she was honored with this title is because her work with fertility prompted women to control their future.


References


External links


National Library of Medicine Biography - Georgeanna Seegar Jones
* ttps://web.archive.org/web/20120317135851/http://www.agosonline.org/InMemoriam/jones-gs-2005.asp American Gynecological and Obstetrical Society - Georgeanna Seegar Jones, M.D.br>The Embryo Project - Arizona State University
{{DEFAULTSORT:Jones, Georgeanna Seegar 1912 births 2005 deaths In vitro fertilisation Goucher College alumni American endocrinologists American gynecologists Johns Hopkins School of Medicine alumni Physicians from Baltimore Women gynaecologists Women endocrinologists Eastern Virginia Medical School faculty 20th-century American physicians 20th-century American women physicians 21st-century American physicians 21st-century American women physicians American women academics