George Herbert Hitchings (April 18, 1905 – February 27, 1998) was an American medical doctor who shared the 1988
Nobel Prize in Physiology or Medicine
The Nobel Prize in Physiology or Medicine is awarded yearly by the Nobel Assembly at the Karolinska Institute for outstanding discoveries in physiology or medicine. The Nobel Prize is not a single prize, but five separate prizes that, accord ...
with
Sir James Black
Sir James Whyte Black (14 June 1924 – 22 March 2010) was a Scottish physician and pharmacologist. Together with Gertrude B. Elion and George H. Hitchings, he shared the Nobel Prize for Medicine in 1988 for pioneering strategies for rational d ...
and
Gertrude Elion
Gertrude "Trudy" Belle Elion (January 23, 1918 – February 21, 1999) was an American biochemist and pharmacologist, who shared the 1988 Nobel Prize in Physiology or Medicine with George H. Hitchings and Sir James Black for their use of innovat ...
"for their discoveries of important principles for drug treatment", Hitchings specifically for his work on
chemotherapy
Chemotherapy (often abbreviated to chemo and sometimes CTX or CTx) is a type of cancer treatment that uses one or more anti-cancer drugs (chemotherapeutic agents or alkylating agents) as part of a standardized chemotherapy regimen. Chemotherap ...
.
Education and early life
Hitchings was born in
Hoquiam, Washington
Hoquiam ( ) is a city in Grays Harbor County, Washington, United States. It borders the city of Aberdeen at Myrtle Street, with Hoquiam to the west. The two cities share a common economic history in lumbering and exporting, but Hoquiam has mainta ...
, in 1905, and grew up there, in
Berkeley, California
Berkeley ( ) is a city on the eastern shore of San Francisco Bay in northern Alameda County, California, United States. It is named after the 18th-century Irish bishop and philosopher George Berkeley. It borders the cities of Oakland and Emer ...
,
San Diego
San Diego ( , ; ) is a city on the Pacific Ocean coast of Southern California located immediately adjacent to the Mexico–United States border. With a 2020 population of 1,386,932, it is the List of United States cities by population, eigh ...
,
Bellingham, Washington
Bellingham ( ) is the most populous city in, and county seat of Whatcom County in the U.S. state of Washington. It lies south of the U.S.–Canada border in between two major cities of the Pacific Northwest: Vancouver, British Columbia (locat ...
, and
Seattle
Seattle ( ) is a seaport city on the West Coast of the United States. It is the seat of King County, Washington. With a 2020 population of 737,015, it is the largest city in both the state of Washington and the Pacific Northwest regio ...
. He graduated from Seattle's
Franklin High School, where he was
salutatorian
Salutatorian is an academic title given in the United States, Armenia, and the Philippines to the second-highest-ranked graduate of the entire graduating class of a specific discipline. Only the valedictorian is ranked higher. This honor is tradi ...
, in 1923, and from there went to the
University of Washington
The University of Washington (UW, simply Washington, or informally U-Dub) is a public research university in Seattle, Washington.
Founded in 1861, Washington is one of the oldest universities on the West Coast; it was established in Seattle a ...
, from which he graduated with a degree in
chemistry
Chemistry is the science, scientific study of the properties and behavior of matter. It is a natural science that covers the Chemical element, elements that make up matter to the chemical compound, compounds made of atoms, molecules and ions ...
''cum laude'' in 1927, after having been elected to
Phi Beta Kappa
The Phi Beta Kappa Society () is the oldest academic honor society in the United States, and the most prestigious, due in part to its long history and academic selectivity. Phi Beta Kappa aims to promote and advocate excellence in the liberal a ...
as a junior the year before. That summer, he worked at the university's
Puget Sound
Puget Sound ( ) is a sound of the Pacific Northwest, an inlet of the Pacific Ocean, and part of the Salish Sea. It is located along the northwestern coast of the U.S. state of Washington. It is a complex estuarine system of interconnected ma ...
Biological Station at
Friday Harbor on
San Juan Island
San Juan Island is the second-largest and most populous of the San Juan Islands in northwestern Washington (state), Washington, United States. It has a land area of 142.59 km2 (55.053 sq mi) and a population of 6,822 as of the United States ...
br>
and received a master's degree the next year for his thesis based on that work.
From the University of Washington, Hitchings went to
Harvard University
Harvard University is a private Ivy League research university in Cambridge, Massachusetts. Founded in 1636 as Harvard College and named for its first benefactor, the Puritan clergyman John Harvard, it is the oldest institution of higher le ...
as a teaching fellow, ending up at Harvard Medical School. Before getting his
Ph.D.
A Doctor of Philosophy (PhD, Ph.D., or DPhil; Latin: or ') is the most common degree at the highest academic level awarded following a course of study. PhDs are awarded for programs across the whole breadth of academic fields. Because it is a ...
in 1933, he joined
Alpha Chi Sigma
Alpha Chi Sigma () is a professional fraternity specializing in the fields of the chemical sciences. It has both collegiate and professional chapters throughout the United States consisting of both men and women and numbering more than 70,000 mem ...
in 1929.
Career and research
Following his PhD, he worked at Harvard and
Case Western Reserve University
Case Western Reserve University (CWRU) is a private research university in Cleveland, Ohio. Case Western Reserve was established in 1967, when Western Reserve University, founded in 1826 and named for its location in the Connecticut Western Reser ...
. In 1942, he went to work for Wellcome Research Laboratories at
Tuckahoe, where he began working with
Gertrude Elion
Gertrude "Trudy" Belle Elion (January 23, 1918 – February 21, 1999) was an American biochemist and pharmacologist, who shared the 1988 Nobel Prize in Physiology or Medicine with George H. Hitchings and Sir James Black for their use of innovat ...
in 1944. Drugs Hitchings' team worked on included
2,6-diaminopurine (a compound to treat
leukemia
Leukemia ( also spelled leukaemia and pronounced ) is a group of blood cancers that usually begin in the bone marrow and result in high numbers of abnormal blood cells. These blood cells are not fully developed and are called ''blasts'' or ' ...
) and p-chlorophenoxy-2,4-diaminopyrimidine (a
folic acid
Folate, also known as vitamin B9 and folacin, is one of the B vitamins. Manufactured folic acid, which is converted into folate by the body, is used as a dietary supplement and in food fortification as it is more stable during processing and ...
antagonist). According to his Nobel Prize autobiography,
:The line of inquiry we had begun in the 1940s
lsoyielded new drug therapies for
malaria
Malaria is a mosquito-borne infectious disease that affects humans and other animals. Malaria causes symptoms that typically include fever, tiredness, vomiting, and headaches. In severe cases, it can cause jaundice, seizures, coma, or death. S ...
(
pyrimethamine
Pyrimethamine, sold under the brand name Daraprim among others, is a medication used with leucovorin (leucovorin is used to decrease side effects of pyrimethamine; it does not have intrinsic anti-parasitic activity) to treat the parasitic disea ...
), leukemia (
6-mercaptopurine
Mercaptopurine (6-MP), sold under the brand name Purinethol among others, is a medication used for cancer and autoimmune diseases. Specifically it is used to treat acute lymphocytic leukemia (ALL), acute promyelocytic leukemia (APL), Crohn's dise ...
and
thioguanine
Tioguanine, also known as thioguanine or 6-thioguanine (6-TG) is a medication used to treat acute myeloid leukemia (AML), acute lymphocytic leukemia (ALL), and chronic myeloid leukemia (CML). Long-term use is not recommended. It is given by mouth. ...
),
gout
Gout ( ) is a form of inflammatory arthritis characterized by recurrent attacks of a red, tender, hot and swollen joint, caused by deposition of monosodium urate monohydrate crystals. Pain typically comes on rapidly, reaching maximal intensit ...
(
allopurinol
Allopurinol is a medication used to decrease high blood uric acid levels. It is specifically used to prevent gout, prevent specific types of kidney stones and for the high uric acid levels that can occur with chemotherapy. It is taken by mouth ...
),
organ transplantation
Organ transplantation is a medical procedure in which an organ (anatomy), organ is removed from one body and placed in the body of a recipient, to replace a damaged or missing organ. The donor and recipient may be at the same location, or organ ...
(
azathioprine
Azathioprine (AZA), sold under the brand name Imuran, among others, is an immunosuppressive medication. It is used in rheumatoid arthritis, granulomatosis with polyangiitis, Crohn's disease, ulcerative colitis, and systemic lupus erythematosus, ...
) and
bacteria
Bacteria (; singular: bacterium) are ubiquitous, mostly free-living organisms often consisting of one biological cell. They constitute a large domain of prokaryotic microorganisms. Typically a few micrometres in length, bacteria were among ...
l
infection
An infection is the invasion of tissues by pathogens, their multiplication, and the reaction of host tissues to the infectious agent and the toxins they produce. An infectious disease, also known as a transmissible disease or communicable dise ...
s (
co-trimoxazole
Trimethoprim/sulfamethoxazole, sold under the brand name Bactrim among others, is a fixed-dose combination antibiotic medication used to treat a variety of bacterial infections. It consists of one part trimethoprim to five parts sulfamethoxazo ...
(trimethoprimA)). The new knowledge contributed by our studies pointed the way for investigations that led to major
antiviral drug
Antiviral drugs are a class of medication used for treating viral infections. Most antivirals target specific viruses, while a broad-spectrum antiviral is effective against a wide range of viruses. Unlike most antibiotics, antiviral drugs do n ...
s for
herpes
Herpes simplex is a viral infection caused by the herpes simplex virus. Infections are categorized based on the part of the body infected.
Oral herpes involves the face or mouth. It may result in small blisters in groups often called cold s ...
infections (
acyclovir
Aciclovir (ACV), also known as acyclovir, is an antiviral medication. It is primarily used for the treatment of herpes simplex virus infections, chickenpox, and shingles. Other uses include prevention of cytomegalovirus infections following tran ...
) and
AIDS
Human immunodeficiency virus infection and acquired immunodeficiency syndrome (HIV/AIDS) is a spectrum of conditions caused by infection with the human immunodeficiency virus (HIV), a retrovirus. Following initial infection an individual m ...
(
zidovudine
Zidovudine (ZDV), also known as azidothymidine (AZT), is an antiretroviral medication used to prevent and treat HIV/AIDS. It is generally recommended for use in combination with other antiretrovirals. It may be used to prevent mother-to-child ...
).
In 1967 Hitchings became Vice President in Charge of Research of Burroughs-Wellcome. He became Scientist Emeritus in 1976. He also served as Adjunct Professor of Pharmacology and of Experimental Medicine from 1970 to 1985 at
Duke University
Duke University is a private research university in Durham, North Carolina. Founded by Methodists and Quakers in the present-day city of Trinity in 1838, the school moved to Durham in 1892. In 1924, tobacco and electric power industrialist James ...
.
Hitchings founded the Triangle Community Foundation in 1983. Hitchings is a member of the Medicinal Chemistry Hall of Fame.
Personal life
His first wife, Beverly Reimer Hitchings, died in 1985. Hitchings remarried in 1989 to Joyce Carolyn Shaver-Hitchings, MD. Dr. Shaver-Hitchings died in 2009.
Hitchings died on 27 February 1998 in
Chapel Hill, North Carolina
Chapel Hill is a town in Orange, Durham and Chatham counties in the U.S. state of North Carolina. Its population was 61,960 in the 2020 census, making Chapel Hill the 17th-largest municipality in the state. Chapel Hill, Durham, and the state ca ...
.
Awards and honors
Hitchings was awarded the Passano award by the
Passano Foundation
The Passano Foundation, established in 1945, provides an annual award to a research scientist whose work – done in the United States – is thought to have immediate practical benefits. Many Passano laureates have subsequently won the Nobel Priz ...
in 1969, and the de Villiers award in 1970. In 1972, he was awarded the
Cameron Prize for Therapeutics of the University of Edinburgh
The Cameron Prize for Therapeutics of the University of Edinburgh is awarded by the College of Medicine and Veterinary Medicine to a person who has made any highly important and valuable addition to Practical Therapeutics in the previous five ye ...
. He was elected a
Foreign Member of the Royal Society (ForMemRS) in 1974.
In 1989, Hitchings received the Golden Plate Award of the
American Academy of Achievement
The American Academy of Achievement, colloquially known as the Academy of Achievement, is a non-profit educational organization that recognizes some of the highest achieving individuals in diverse fields and gives them the opportunity to meet o ...
.
References
External links
*
{{DEFAULTSORT:Hitchings, George H.
1905 births
1998 deaths
Harvard Fellows
Case Western Reserve University faculty
People from Hoquiam, Washington
Physicians from Seattle
American pharmacologists
Harvard Medical School alumni
University of Washington College of Arts and Sciences alumni
Duke University faculty
Nobel laureates in Physiology or Medicine
American Nobel laureates
Foreign Members of the Royal Society
Franklin High School (Seattle) alumni