George Nikov Chaldakov (

Bulgarian Bulgarian may refer to: * Something of, from, or related to the country of Bulgaria * Bulgarians, a South Slavic ethnic group * Bulgarian language, a Slavic language * Bulgarian alphabet * A citizen of Bulgaria, see Demographics of Bulgaria * Bul ...

: Георги Ников Чалдъков) born February 23, 1940, in

Burgas, Bulgaria Burgas ( bg, Бургас, ), sometimes transliterated as ''Bourgas'', is the second largest city on the Bulgarian Black Sea Coast in the region of Northern Thrace and the fourth-largest in Bulgaria after Sofia, Plovdiv, and Varna, with a popul ...

, is a

Bulgaria Bulgaria (; bg, България, Bǎlgariya), officially the Republic of Bulgaria,, ) is a country in Southeast Europe. It is situated on the eastern flank of the Balkans, and is bordered by Romania to the north, Serbia and North Macedon ...

n vascular biologist well known for his contributions to the study of secretory function of

vascular smooth muscle Vascular smooth muscle is the type of smooth muscle that makes up most of the walls of blood vessels. Structure Vascular smooth muscle refers to the particular type of smooth muscle found within, and composing the majority of the wall of blood ...

cells, and the role of

neurotrophin Neurotrophins are a family of proteins that induce the survival, development, and function of neurons. They belong to a class of growth factors, secreted proteins that can signal particular cells to survive, differentiate, or grow. Growth factor ...

s and perivascular

adipose tissue Adipose tissue, body fat, or simply fat is a loose connective tissue composed mostly of adipocytes. In addition to adipocytes, adipose tissue contains the stromal vascular fraction (SVF) of cells including preadipocytes, fibroblasts, vascular e ...

pathogenesis Pathogenesis is the process by which a disease or disorder develops. It can include factors which contribute not only to the onset of the disease or disorder, but also to its progression and maintenance. The word comes from Greek πάθος ''pat ...

atherosclerosis Atherosclerosis is a pattern of the disease arteriosclerosis in which the wall of the artery develops abnormalities, called lesions. These lesions may lead to narrowing due to the buildup of atheroma, atheromatous plaque. At onset there are usu ...

. He published the first Bulgarian textbook of

Cell Biology Cell biology (also cellular biology or cytology) is a branch of biology that studies the structure, function, and behavior of cells. All living organisms are made of cells. A cell is the basic unit of life that is responsible for the living and ...

in 1996 and in 2005 founded the ''Bulgarian Society for Cell Biology''. In 1966 Chaldakov graduated as an MD from Varna Institute of Medicine (since 1991, named

Medical University of Varna The Medical University of Varna (MU-Varna) is a Bulgarian state school for higher education dedicated to training specialists in the fields of medicine and healthcare who graduate with the educational and qualification degrees of Master, Bachelor ...

Varna, Bulgaria Varna ( bg, Варна, ) is the third-largest List of cities and towns in Bulgaria, city in Bulgaria and the largest city and seaside resort on the Bulgarian Black Sea Coast and in the Northern Bulgaria region. Situated strategically in the ...

. In 1983 he obtained a

PhD PHD or PhD may refer to: * Doctor of Philosophy (PhD), an academic qualification Entertainment * '' PhD: Phantasy Degree'', a Korean comic series * ''Piled Higher and Deeper'', a web comic * Ph.D. (band), a 1980s British group ** Ph.D. (Ph.D. albu ...

in Vascular Biology, ''"Ultrastructural and cytopharmacological study of aging in vascular smooth muscle cells, with special reference to their secretory function"''. Since 2007, Chaldakov has served as

Professor Emeritus ''Emeritus'' (; female: ''emerita'') is an adjective used to designate a retired chair, professor, pastor, bishop, pope, director, president, prime minister, rabbi, emperor, or other person who has been "permitted to retain as an honorary title ...

at Medical University of Varna, Bulgaria. For the past 30 years Chaldakov has been involved in interdisciplinary research in the fields of vascular biology, and has had relationship with such adipobiology, and

neurobiology Neuroscience is the scientific study of the nervous system (the brain, spinal cord, and peripheral nervous system), its functions and disorders. It is a multidisciplinary science that combines physiology, anatomy, molecular biology, development ...

and is one of the pioneers establishing the novel concept of the secretory function/

phenotype In genetics, the phenotype () is the set of observable characteristics or traits of an organism. The term covers the organism's morphology or physical form and structure, its developmental processes, its biochemical and physiological proper ...

of the vascular smooth muscle cells and further delineating their role in

atherogenesis Atherosclerosis is a pattern of the disease arteriosclerosis in which the wall of the artery develops abnormalities, called lesions. These lesions may lead to narrowing due to the buildup of atheromatous plaque. At onset there are usually no sy ...

. Chaldakov developed a complex tripartite model of atherogenesis which involve smooth muscle cells,

immune cell White blood cells, also called leukocytes or leucocytes, are the cells of the immune system that are involved in protecting the body against both infectious disease and foreign invaders. All white blood cells are produced and derived from mult ...

s, and perivascular adipose tissue communicating through secreted factors (e.g.

adipokine The adipokines, or adipocytokines (Greek ', fat; ', cell; and ', movement) are cytokines (cell signaling proteins) secreted by adipose tissue. Some contribute to an obesity-related low-grade state of inflammation or to the development of metabolic ...

cytokine Cytokines are a broad and loose category of small proteins (~5–25 kDa) important in cell signaling. Cytokines are peptides and cannot cross the lipid bilayer of cells to enter the cytoplasm. Cytokines have been shown to be involved in autocrin ...

s). In 1991, Chaldakov became founder and chief editor of ''Biomedical Reviews, An International Journal of Cell Biology of Disease. He has also been an'' organizer of ''Biomedical Forum, Annual Program of Continuing Medical Education'' held at Medical University of Varna, Bulgaria.

Innovations and substantial contributions to science

Concept Concepts are defined as abstract ideas. They are understood to be the fundamental building blocks of the concept behind principles, thoughts and beliefs. They play an important role in all aspects of cognition. As such, concepts are studied by s ...

of the secretory function/

of the

vascular smooth muscle cell Vascular smooth muscle is the type of smooth muscle that makes up most of the walls of blood vessels. Structure Vascular smooth muscle refers to the particular type of smooth muscle found within, and composing the majority of the wall of blood ve ...

, as related to

. *

Tubulin Tubulin in molecular biology can refer either to the tubulin protein superfamily of globular proteins, or one of the member proteins of that superfamily. α- and β-tubulins polymerize into microtubules, a major component of the eukaryotic cytoske ...

microtubule Microtubules are polymers of tubulin that form part of the cytoskeleton and provide structure and shape to eukaryotic cells. Microtubules can be as long as 50 micrometres, as wide as 23 to 27 nm and have an inner diameter between 11 an ...

-targeted

pharmacology Pharmacology is a branch of medicine, biology and pharmaceutical sciences concerned with drug or medication action, where a drug may be defined as any artificial, natural, or endogenous (from within the body) molecule which exerts a biochemica ...

for atherosclerosis. * Concept of the

s NGF and

BDNF Brain-derived neurotrophic factor (BDNF), or abrineurin, is a protein found in the and the periphery. that, in humans, is encoded by the ''BDNF'' gene. BDNF is a member of the neurotrophin family of growth factors, which are related to the cano ...

as metabotrophic factors (metabotrophins) in cardiometabolic biology/diseases. * Conceptualize the protein secretory products of

cells as adipokines, also focusing on perivascular adipose tissue. * Conceptualize studying adipose tissue-directed pharmacology as adipopharmacology. * In 2006 introduced the term ''Homo obesus'' and is actively involved in popularizing the need of healthy

lifestyle Lifestyle often refers to: * Lifestyle (sociology), the way a person lives * ''Otium'', ancient Roman concept of a lifestyle * Style of life (german: Lebensstil, link=no), dealing with the dynamics of personality Lifestyle may also refer to: Bus ...

and dietary restriction: millions of people suffer and die from starvation in ill-developed and poor countries while in

Western world The Western world, also known as the West, primarily refers to the various nations and state (polity), states in the regions of Europe, North America, and Oceania.

and

Europe Europe is a large peninsula conventionally considered a continent in its own right because of its great physical size and the weight of its history and traditions. Europe is also considered a Continent#Subcontinents, subcontinent of Eurasia ...

people get

overweight Being overweight or fat is having more body fat than is optimally healthy. Being overweight is especially common where food supplies are plentiful and lifestyles are sedentary. , excess weight reached epidemic proportions globally, with mo ...

and die as a result of

stroke A stroke is a medical condition in which poor blood flow to the brain causes cell death. There are two main types of stroke: ischemic, due to lack of blood flow, and hemorrhagic, due to bleeding. Both cause parts of the brain to stop functionin ...

s or heart infarctions.

References and notes

External links

Bulgarian Society for Cell Biology

Biomedical Reviews

Adipobiology

The European Atherosclerosis Society

Medical University of Varna Website
{{DEFAULTSORT:Chaldakov, George Bulgarian medical researchers Bulgarian biologists Living people 1940 births