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Geoffrey Sharman Dawes,
CBE The Most Excellent Order of the British Empire is a British order of chivalry, rewarding contributions to the arts and sciences, work with charitable and welfare organisations, and public service outside the civil service. It was established o ...
, FRS, FRCOG, FRCP, FACOG(Hon), FAAP(Hon) (21 January 1918 – 6 May 1996) was an English physiologist and was considered to be the foremost international authority on fetal and neonatal physiology.Obituary: Professor Geoffrey Dawes
Independent, The (London), 16 May 1996 by C.W.G. Redman. Retrieved 7 September 2008


Biography

Dawes was born in 1918 in Mackworth which is within
Derbyshire Derbyshire ( ) is a ceremonial county in the East Midlands, England. It includes much of the Peak District National Park, the southern end of the Pennine range of hills and part of the National Forest. It borders Greater Manchester to the nor ...
, but he was brought up in Elvaston where his father was the vicar of Elvaston and Thulston. He had four siblings who were all older than he was. Dawes lived at Thurleston Hall, the vicarage for Elvaston. This hall had previously been the home of
William Darwin Fox The Reverend William Darwin Fox (23 April 1805 – 8 April 1880) was an English clergyman, naturalist, and a second cousin of Charles Darwin. Early life Fox was born in 1805 and initially raised at Thurleston Grange near Elvaston, Derbys ...
. His prep school was in the next village of
Shardlow Shardlow is a village in Derbyshire, England about southeast of Derby and southwest of Nottingham. Part of the civil parish of Shardlow and Great Wilne, and the district of South Derbyshire, it is also very close to the border with Leice ...
, where he studied until he started at
Repton School Repton School is a 13–18 co-educational, independent, day and boarding school in the English public school tradition, in Repton, Derbyshire, England. Sir John Port of Etwall, on his death in 1557, left funds to create a grammar school whi ...
which was still within south Derbyshire. This association with Repton continued as later he would become both a member and later chair of their governors. As
World War II World War II or the Second World War, often abbreviated as WWII or WW2, was a world war that lasted from 1939 to 1945. It involved the vast majority of the world's countries—including all of the great powers—forming two opposing ...
was beginning, he gained a place at
Oxford University Oxford () is a city in England. It is the county town and only city of Oxfordshire. In 2020, its population was estimated at 151,584. It is north-west of London, south-east of Birmingham and north-east of Bristol. The city is home to th ...
, eventually achieving a 1st in
physiology Physiology (; ) is the scientific study of functions and mechanisms in a living system. As a sub-discipline of biology, physiology focuses on how organisms, organ systems, individual organs, cells, and biomolecules carry out the chemical ...
in 1943. Suffering from
asthma Asthma is a long-term inflammatory disease of the airways of the lungs. It is characterized by variable and recurring symptoms, reversible airflow obstruction, and easily triggered bronchospasms. Symptoms include episodes of wheezing, co ...
, he was considered exempt from conscription, and by 1943 had completed his clinical training. Unable to go into the military, he joined J H Burn in the department of pharmacology, treating the sort of diseases and complaints that soldiers of the front suffered from during World War I, like
gas gangrene Gas gangrene (also known as clostridial myonecrosis and myonecrosis) is a bacterial infection that produces tissue gas in gangrene. This deadly form of gangrene usually is caused by '' Clostridium perfringens'' bacteria. About 1,000 cases of gas ...
and
nerve gas Nerve agents, sometimes also called nerve gases, are a class of organic chemicals that disrupt the mechanisms by which nerves transfer messages to organs. The disruption is caused by the blocking of acetylcholinesterase (AChE), an enzyme that ...
exposure. When the war ended, he was awarded a
Rockefeller Rockefeller is a German surname, originally given to people from the village of Rockenfeld near Neuwied in the Rhineland and commonly referring to subjects associated with the Rockefeller family. It may refer to: People with the name Rockefeller f ...
travelling fellowship, travelling to America to work at
Harvard University Harvard University is a private Ivy League research university in Cambridge, Massachusetts. Founded in 1636 as Harvard College and named for its first benefactor, the Puritan clergyman John Harvard, it is the oldest institution of high ...
and in Philadelphia. He returned to work in Oxford on a Foulerton Royal Society research fellowship.


Career

Dawes became the director of the Nuffield Institute for Medical research in Oxford in 1948 only five years after obtaining his degree in medicine,Historical Perspectives – Perinatal Profiles: Geoffrey S. Dawes: A Neonatologist's Appreciation
NeoReviews Vol. 8 No. 9 2007 e365. Retrieved 7 September 2008
and where he worked for the next 37 years, and setting the Institutes research focus on developmental physiology. Following his appointment as director Dawes had to decide on an area of research that was worthy of his attention. He decided on
fetal A fetus or foetus (; plural fetuses, feti, foetuses, or foeti) is the unborn offspring that develops from an animal embryo. Following embryonic development the fetal stage of development takes place. In human prenatal development, fetal develo ...
physiology Physiology (; ) is the scientific study of functions and mechanisms in a living system. As a sub-discipline of biology, physiology focuses on how organisms, organ systems, individual organs, cells, and biomolecules carry out the chemical ...
as he thought at the time that study of fetuses would allow researchers to study simpler version of more complex adult physiology. This was not the case and Dawes himself became a spokesman for the importance and complexity of this stage of physiology. His initial research was conducted into the distribution and control of fetal circulation, mostly in unborn
lamb Lamb or The Lamb may refer to: * A young sheep * Lamb and mutton, the meat of sheep Arts and media Film, television, and theatre * ''The Lamb'' (1915 film), a silent film starring Douglas Fairbanks Sr. in his screen debut * ''The Lamb'' (1918 ...
fetus. He studied
chemoreceptor A chemoreceptor, also known as chemosensor, is a specialized sensory receptor which transduces a chemical substance (endogenous or induced) to generate a biological signal. This signal may be in the form of an action potential, if the chemorecept ...
s, the biological mechanism that start the changes in birth. In particular he studied the onset of breathing, for the implications for human physiology, and changes in the pulmonary and systemic circulations. Dawes was one of the first paediatricians to observe that lamb fetus had
sleep Sleep is a sedentary state of mind and body. It is characterized by altered consciousness, relatively inhibited sensory activity, reduced muscle activity and reduced interactions with surroundings. It is distinguished from wakefulness by a de ...
cycles as well as breathing cycles
In utero ''In Utero'' is the third and final studio album by American rock band Nirvana. It was released on September 21, 1993, by DGC Records. After breaking into the mainstream with their second album, ''Nevermind'' (1991), Nirvana hired Steve Albin ...
. Studies also included the responses to stresses such as hypoxia and
hemorrhage Bleeding, hemorrhage, haemorrhage or blood loss, is blood escaping from the circulatory system from damaged blood vessels. Bleeding can occur internally, or externally either through a natural opening such as the mouth, nose, ear, urethra, v ...
. Using this research, he was able to determine and later confirm that human fetus also slept in cycles. This led Dawes to consider the role of the central nervous control, not only in relation to sleep states, but also heart rate variability and responses to the stimulation of chemoreceptors. Using his research Dawes designed a system of measurement, used in obstetric departments around the world, as the most precise non-invasive way of assessing the well-being of the human fetus. Dawes was awarded the
Gairdner Foundation International Award The Canada Gairdner International Award is given annually by the Gairdner Foundation at a special dinner to five individuals for outstanding discoveries or contributions to medical science. Receipt of the Gairdner is traditionally considered a ...
in 1966 for his outstanding contributions to medical science. He was elected a
Fellow of the Royal Society Fellowship of the Royal Society (FRS, ForMemRS and HonFRS) is an award granted by the judges of the Royal Society of London to individuals who have made a "substantial contribution to the improvement of natural knowledge, including mathemat ...
in March 1971. Dawes was an editor of the
British Journal of Pharmacology The ''British Journal of Pharmacology'' is a biweekly peer-reviewed medical journal covering all aspects of experimental pharmacology. It is published for the British Pharmacological Society by Wiley-Blackwell. It was established in 1946 as th ...
for many years. He won the
James Spence Medal James Spence Medal is a medal that was first struck in 1960, six years after the death of the paediatrician James Calvert Spence and is awarded for outstanding contributions to the advancement or clarification of Pediatrics, paediatric knowledge a ...
in 1969, that is awarded by the Royal College of Paediatrics and Child Health for outstanding contributions to the advancement or clarification of paediatric knowledge, the Virginia Apgar award of the American Academy of Paediatrics, the Osler Memorial Medal of
Oxford University Oxford () is a city in England. It is the county town and only city of Oxfordshire. In 2020, its population was estimated at 151,584. It is north-west of London, south-east of Birmingham and north-east of Bristol. The city is home to th ...
and many more. Dawes retired in 1985 and took up the post of director of Sunley Research Centre at
Charing Cross Hospital Charing Cross Hospital is an acute general teaching hospital located in Hammersmith, London, United Kingdom. The present hospital was opened in 1973, although it was originally established in 1818, approximately five miles east, in central L ...
, where he worked on both the computerisation of fetal heart rates and on molecular biology. The Nuffield Institute of Medical research which he had directed became part of the Institute of Molecular Medicine, when Dawes finally retired in 1989. Upon retirement, and still fully fit with an acute mind, he was recruited as first director of the Sunley Research Centre at
Charing Cross Hospital Charing Cross Hospital is an acute general teaching hospital located in Hammersmith, London, United Kingdom. The present hospital was opened in 1973, although it was originally established in 1818, approximately five miles east, in central L ...
. A keen entertainer with his wife Margaret with two sons and two daughters, he died in Oxford in 1996.


Publications

*''Fetal and Neonatal Physiology'' (1968)


Awards and honours

* 1963 Max Weinstein Award, USA. * 1966 Gairdner Foundation Award, Canada. * 1969
James Spence Medal James Spence Medal is a medal that was first struck in 1960, six years after the death of the paediatrician James Calvert Spence and is awarded for outstanding contributions to the advancement or clarification of Pediatrics, paediatric knowledge a ...
British Paediatric Association The Royal College of Paediatrics and Child Health, often referred to as the RCPCH, is the professional body for paediatricians (doctors specialising in child health) in the United Kingdom. It is responsible for the postgraduate training of paed ...
. Fellow,
Royal College of Obstetricians and Gynaecologists The Royal College of Obstetricians and Gynaecologists (RCOG) is a professional association based in London, United Kingdom. Its members, including people with and without medical degrees, work in the field of obstetrics and gynaecology, that ...
. * 1971 Fellow,
Royal Society The Royal Society, formally The Royal Society of London for Improving Natural Knowledge, is a learned society and the United Kingdom's national academy of sciences. The society fulfils a number of roles: promoting science and its benefits, re ...
, London. * 1972 Fellow,
Royal College of Physicians The Royal College of Physicians (RCP) is a British professional membership body dedicated to improving the practice of medicine, chiefly through the accreditation of physicians by examination. Founded by royal charter from King Henry VIII in 1 ...
. * 1974 Fellow, American Congress of Obstetricians and Gynecologists. * 1976 Fellow, American Academy of Pediatrics. * 1981 C.B.E. * 1981 Blair Bell Gold Medal,
Royal Society of Medicine The Royal Society of Medicine (RSM) is a medical society in the United Kingdom, headquartered in London. History The Society was established in 1805 as Medical and Chirurgical Society of London, meeting in two rooms in barristers’ chamber ...
. * 1982 Honorary DMed University of Gothenburg, Sweden. * 1990 Osler Memorial Medal, Oxford University. The Geoffrey Dawes lecture is given annually and organised by the ''Fetal and Neonatal Physiological Society''.Fetal and Neonatal Physiological Society
Retrieved 7 September 2008


References

{{DEFAULTSORT:Dawes, Geoffrey Sharman 1918 births 1996 deaths People from Mackworth British physiologists Commanders of the Order of the British Empire Fellows of the Royal Society People educated at Shardlow Hall Recipients of the James Spence Medal Fellows of the Royal College of Physicians