Gemeprost (16, 16-dimethyl-trans-delta2 PGE
1 methyl ester) is an
analogue of
prostaglandin E1.
Clinical use
It is used as a treatment for
obstetric bleeding.
It is used with
mifepristone
Mifepristone, also known as RU-486, is a medication typically used in combination with misoprostol to bring about a medical abortion during pregnancy and manage early miscarriage. This combination is 97% effective during the first 63 days of p ...
to terminate pregnancy up to 24 weeks gestation.
Side effects
Vaginal bleeding, cramps, nausea, vomiting,
loose stools or diarrhea,
headache, muscle weakness; dizziness; flushing; chills; backache; dyspnoea; chest pain; palpitations and mild
pyrexia
Fever, also referred to as pyrexia, is defined as having a temperature above the normal range due to an increase in the body's temperature set point. There is not a single agreed-upon upper limit for normal temperature with sources using val ...
.
Rare: Uterine rupture, severe
hypotension
Hypotension is low blood pressure. Blood pressure is the force of blood pushing against the walls of the arteries as the heart pumps out blood. Blood pressure is indicated by two numbers, the systolic blood pressure (the top number) and the dias ...
, coronary spasms with subsequent
myocardial infarction
A myocardial infarction (MI), commonly known as a heart attack, occurs when blood flow decreases or stops to the coronary artery of the heart, causing damage to the heart muscle. The most common symptom is chest pain or discomfort which may ...
s.
References
External links
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Abortifacients
Prostaglandins
Sanofi
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