''GBA2'' is the
gene
In biology, the word gene (from , ; "... Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ''birth'' or ''gender'') can have several different meanings. The Mendelian gene is a b ...
that encodes the
enzyme
Enzymes () are proteins that act as biological catalysts by accelerating chemical reactions. The molecules upon which enzymes may act are called substrates, and the enzyme converts the substrates into different molecules known as products ...
non-lysosomal glucosylceramidase in humans.
It has
glucosylceramidase
In enzymology, a glucosylceramidase () is an enzyme that catalyzes the chemical reaction
:D-glucosyl-N-acylsphingosine + H2O \rightleftharpoons D-glucose + N-acylsphingosine
Thus, the two substrates of this enzyme are D-glucosyl-N-acylsphingo ...
() activity.
Function
This gene encodes a microsomal beta-glucosidase that catalyzes the hydrolysis of bile acid 3-O-glucosides as endogenous compounds. Studies to determine subcellular localization of this protein in the liver indicated that the enzyme was mainly enriched in the microsomal fraction where it appeared to be confined to the endoplasmic reticulum. This putative transmembrane protein is thought to play a role in carbohydrate transport and metabolism.
See also
* Closely related enzymes
**
GBA: acid β-glucosidase (lysosomal),
**
GBA3
Cytosolic beta-glucosidase, also known as cytosolic beta-glucosidase-like protein 1, is a beta-glucosidase () enzyme that in humans is encoded by the ''GBA3'' gene.
Function
Cytosolic beta-glucosidase is a predominantly liver enzyme that effic ...
: acid β-glucosidase (cytosolic),
References
Further reading
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EC 3.2.1
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