Gardiquimod is an experimental drug which acts selectively at both mouse and human forms of

toll-like receptor 7 Toll-like receptor 7, also known as TLR7, is a protein that in humans is encoded by the ''TLR7'' gene. Orthologs are found in mammals and birds. It is a member of the toll-like receptor (TLR) family and detects single stranded RNA. Function T ...

(TLR7). It functions as an immune response modifier. The core structure is 1''H''-imidazo ,5-cuinoline, as found in related drugs such as

imiquimod Imiquimod, sold under the brand name Aldara among others, is a medication that acts as an immune response modifier that is used to treat genital warts, superficial basal cell carcinoma, and actinic keratosis. Scientists at 3M's pharmaceuticals ...

and

resiquimod Resiquimod (R-848) is a drug that acts as an immune response modifier, and has Antiviral drug, antiviral and antitumour activity. It is used as a topical gel in the treatment of skin lesions such as those caused by the herpes simplex virus and cu ...

. It is structurally very similar to resiquimod differing only by an oxygen for nitrogen switch.

References

{{Reflist, 30em Antineoplastic and immunomodulating drugs Imidazoquinolines Tertiary alcohols Experimental drugs