Gap junction
Gap junctions are specialized intercellular connections between a multitude of animal cell-types. They directly connect the cytoplasm of two cells, which allows various molecules, ions and electrical impulses to directly pass through a regulate ...
protein
Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residues. Proteins perform a vast array of functions within organisms, including catalysing metabolic reactions, DNA replication, respo ...
s
;Gap junction α (GJA) proteins
*
GJA1
Gap junction alpha-1 protein (GJA1), also known as connexin 43 (Cx43), is a protein that in humans is encoded by the ''GJA1'' gene on chromosome 6. As a connexin, GJA1 is a component of gap junctions, which allow for gap junction intercellular ...
, gap junction alpha-1 protein
*
GJA2, gap junction alpha-2 protein
*
GJA3
Gap junction alpha-3 protein is a protein that in humans is encoded by the ''GJA3'' gene.
Interactions
GJA3 has been shown to Protein-protein interaction, interact with Tight junction protein 1.
References
Further reading
*
*
*
*
*
*
*
*
* ...
, gap junction alpha-3 protein
*
GJA4, gap junction alpha-4 protein
*
GJA5, gap junction alpha-5 protein
*
GJA6, gap junction alpha-6 protein
*
GJA7, gap junction alpha-7 protein
*
GJA8
Gap junction alpha-8 protein is a protein that in humans is encoded by the ''GJA8'' gene. It is also known as connexin 50.
Related gene problems
*1q21.1 deletion syndrome
*1q21.1 duplication syndrome
*microphthalmia and other vision pathologie ...
, gap junction alpha-8 protein
*
GJA9, gap junction alpha-9 protein
*
GJA10, gap junction alpha-10 protein
*
GJA11, gap junction alpha-11 protein
*
GJA12
Gap junction gamma-2 (GJC2), also known as connexin-46.6 (Cx46.6) and connexin-47 (Cx47) and gap junction alpha-12 (GJA12), is a protein that in humans is encoded by the ''GJC2'' gene.
Function
This gene encodes a gap junction protein. Gap jun ...
, gap junction alpha-12 protein
;Gap junction β (GJB) proteins
*
GJB1
Gap junction beta-1 protein (GJB1), also known as connexin 32 (Cx32) is a transmembrane protein that in humans is encoded by the ''GJB1'' gene. Gap junction beta-1 protein is a member of the gap junction connexin family of proteins that regulates ...
, gap junction beta-1 protein
*
GJB2
Gap junction beta-2 protein (GJB2), also known as connexin 26 (Cx26) — is a protein that in humans is encoded by the ''GJB2'' gene.
Clinical significance
Defects in this gene lead to the most common form of congenital deafness in developed c ...
, gap junction beta-2 protein
*
GJB3, gap junction beta-3 protein
*
GJB4, gap junction beta-4 protein
*
GJB5, gap junction beta-5 protein
*
GJB6
Gap junction beta-6 protein (GJB6), also known as connexin 30 (Cx30) — is a protein that in humans is encoded by the ''GJB6'' gene. Connexin 30 (Cx30) is one of several gap junction proteins expressed in the inner ear. Mutations in gap junction ...
, gap junction beta-6 protein
*
GJB7, gap junction beta-7 protein
;Gap junction γ (GJC) proteins
*
GJC1
Gap junction gamma-1 protein (GJC1), also known as gap junction alpha-7 protein (GJA7) and connexin 45 (Cx45) — is a protein that in humans is encoded by the ''GJC1'' gene.
Function
This gene is a member of the connexin gene family. The enco ...
, gap junction gamma-1 protein
*
GJC2
Gap junction gamma-2 (GJC2), also known as connexin-46.6 (Cx46.6) and connexin-47 (Cx47) and gap junction alpha-12 (GJA12), is a protein that in humans is encoded by the ''GJC2'' gene.
Function
This gene encodes a gap junction protein. Gap ju ...
, gap junction gamma-2 protein
*
GJC3
Gap junction gamma-3, also known as connexin-29 (Cx29) or gap junction epsilon-1 (GJE1), is a protein that in humans is encoded by the ''GJC3'' gene.
GJC3 is a conexin.
Function
This gene encodes a gap junction protein. The encoded protein is ...
, gap junction gamma-3 protein
;Gap junction δ (GJD) proteins
*
GJD1, gap junction delta-1 protein
*
GJD2
Gap junction delta-2 protein (GJD2) also known as connexin-36 (Cx36) or gap junction alpha-9 protein (GJA9) is a protein that in humans is encoded by the ''GJD2'' gene.
Function
GJD2, also called connexin-36 (CX36), is a member of the connexin ...
, gap junction delta-2 protein
*
GJD3, gap junction delta-3 protein
*
GJD4, gap junction delta-4 protein
See also
*
Tight junction protein
{{SIA