γ-Humulene synthase (EC 4.2.3.56, humulene cyclase) is an enzyme with systematic name (2''E'',6''E'')-farnesyl-diphosphate diphosphate-lyase (γ-humulene-forming). This enzyme catalyses the following chemical reaction : (2''E'',6''E'')-farnesyl diphosphate

\rightleftharpoons

γ-humulene + diphosphate

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* {{Portal bar, Biology, border=no EC 4.2.3