Guanylyl cyclase-
activating protein 2 is an
enzyme that in
humans is encoded by the ''GUCA1B''
gene.
Alternative names:
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Guanylate cyclase activator 1B
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Retinal
guanylyl
Guanosine monophosphate (GMP), also known as 5′-guanidylic acid or guanylic acid ( conjugate base guanylate), is a nucleotide that is used as a monomer in RNA. It is an ester of phosphoric acid with the nucleoside guanosine. GMP consists ...
cyclase activator
protein p24
Biological Role
Guanylyl cyclase-activating protein 2 is proposed to play a role in
dark adaptation
Darkness, the direct opposite of lightness, is defined as a lack of illumination, an absence of visible light, or a surface that absorbs light, such as black or brown.
Human vision is unable to distinguish colors in conditions of very low l ...
.
Under
scotopic conditions, calcium ions bind to three putative EF-hand calcium binding motifs which reduces the protein's ability to stimulate
guanylyl cyclase.
This contributes to the maintained responsiveness of rod photoreceptors through hyperpolarizing them during sustained darkness.
References
Further reading
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External links
GeneReviews/NCBI/NIH/UW entry on Retinitis Pigmentosa Overview
EF-hand-containing proteins
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