GSK417651A is a chemical compound which acts as a blocker of the

TRPC TRPC is a family of transient receptor potential cation channels in animals. TRPC channels form the subfamily of channels in humans most closely related to drosophila TRP channels. Structurally, members of this family possess a number of similar ...

family of calcium channels, with selectivity for the

TRPC3 Short transient receptor potential channel 3 (TrpC3) also known as transient receptor protein 3 (TRP-3) is a protein that in humans is encoded by the TRPC3 gene. The TRPC3/6/7 subfamily are implicated in the regulation of vascular tone, cell growt ...

and

TRPC6 Transient receptor potential cation channel, subfamily C, member 6, also known as TRPC6, is a human gene encoding a protein of the same name. TRPC6 is a transient receptor potential channel of the classical TRPC subfamily. It has been associated ...

subtypes. It has been used to investigate the role of TRPC3/6 channels in heart function.

References

{{Transient receptor potential channel modulators Thiazoles Ketones Nitrogen heterocycles Amines