GRAd-COV2 is a

COVID-19 vaccine A COVID19 vaccine is a vaccine intended to provide acquired immunity against severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2), the virus that causes coronavirus disease 2019 ( COVID19). Prior to the COVID19 pandemic, an e ...

candidate developed by ReiThera Srl and

Lazzaro Spallanzani National Institute for Infectious Diseases The Lazzaro Spallanzani National Institute for Infectious Diseases (Italian: ''Istituto nazionale per le malattie infettive "L. Spallanzani"'') is an infectious disease hospital in the Italian city of Rome. The institute is named for the eighteenth- ...

. It is based on a novel replication defective Gorilla Adenovirus and encodes for SARS-COV-2 full length prefusion stabilized Spike protein. More specifically, the vector used is the simian group C adenovirus GRAd32, isolated from a captive gorilla, with a genome deleted of the entire E1 and E3 regions and the native E4 region replaced with the E4 orf6 of human adenovirus 5 (hAd5).

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Adenoviridae Clinical trials related to COVID-19 Italian COVID-19 vaccines Science and technology in Italy Viral vector vaccines {{COVID19-vaccine-stub