GR-127935 is a
drug which acts as a
selective antagonist at the
serotonin receptor
Receptor may refer to:
* Sensory receptor, in physiology, any structure which, on receiving environmental stimuli, produces an informative nerve impulse
*Receptor (biochemistry), in biochemistry, a protein molecule that receives and responds to a ...
s
5-HT1B and
5-HT1D.
It has little effect when given by itself but blocks the
antiaggressive effect of 5-HT
1B agonists,
and alters release of serotonin in the brain,
as well as reducing drug-seeking behaviour in cocaine addicted rats.
See also
*
Elzasonan
Elzasonan (CP-448,187) is a selective 5-HT1B and 5-HT1D receptor antagonist that was under development by Pfizer for the treatment of depression but was discontinued, possibly due to poor efficacy. By preferentially blocking 5-HT1B and 5-HT1D ...
References
5-HT1 antagonists
Piperazines
Phenol ethers
Benzanilides
Oxadiazoles
{{nervous-system-drug-stub