Protein wntless homolog, commonly known as Wntless, is encoded in humans by the ''WLS''
gene
In biology, the word gene (from , ; "...Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ''birth'' or ''gender'') can have several different meanings. The Mendelian gene is a ba ...
.
Wntless is a receptor for
Wnt proteins
The Wnt signaling pathways are a group of signal transduction pathways which begin with proteins that pass signals into a cell through cell surface receptors. The name Wnt is a portmanteau created from the names Wingless and Int-1. Wnt signaling p ...
in Wnt-secreting cells.
Wntless was shown to be a cargo for the
retromer Retromer is a complex of proteins that has been shown to be important in recycling transmembrane receptors from endosomes to the Golgi apparatus, ''trans''-Golgi network (TGN).
Background
Retromer is a heteropentameric complex, which in humans i ...
complex.
It has been found essential for hair follicle induction.
A
homozygous
Zygosity (the noun, zygote, is from the Greek "yoked," from "yoke") () is the degree to which both copies of a chromosome or gene have the same genetic sequence. In other words, it is the degree of similarity of the alleles in an organism.
Mo ...
missense mutation
In genetics, a missense mutation is a point mutation in which a single nucleotide change results in a codon that codes for a different amino acid. It is a type of nonsynonymous substitution.
Substitution of protein from DNA mutations
Missense m ...
in the ''WLS'' gene was identified in
Zaki syndrome.
References
Further reading
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See also
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{{G protein-coupled receptors
G protein-coupled receptors