Guanine nucleotide-binding protein G(i), alpha-2 subunit is a
protein
Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residues. Proteins perform a vast array of functions within organisms, including catalysing metabolic reactions, DNA replication, respo ...
that in humans is encoded by the ''GNAI2''
gene
In biology, the word gene (from , ; "...Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ''birth'' or ''gender'') can have several different meanings. The Mendelian gene is a ba ...
.
Interactions
GNAI2 has been shown to
interact
Advocates for Informed Choice, dba interACT or interACT Advocates for Intersex Youth, is a 501(c)(3) nonprofit organization using innovative strategies to advocate for the legal and human rights of children with intersex traits. The organizati ...
with:
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EYA2
Eyes absent homolog 2 is a protein that in humans is encoded by the ''EYA2'' gene.
Function
This gene encodes a member of the eyes absent (EYA) subfamily of proteins. The encoded protein may be post-translationally modified and may play a rol ...
,
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GPSM2
G-protein-signaling modulator 2, also called LGN for its 10 Leucine-Glycine-Asparagine repeats, is a protein that in humans is encoded by the ''GPSM2'' gene.
Function
Heterotrimeric G proteins transduce extracellular signals received by cell s ...
,
*
Interleukin 8 receptor, alpha
Interleukin 8 receptor, alpha is a chemokine receptor. This name and the corresponding gene symbol IL8RA have been replaced by the HGNC approved name C-X-C motif chemokine receptor 1 and the approved symbol CXCR1. It has also been designated as CD ...
,
*
MDFI
MyoD family inhibitor is a protein that in humans is encoded by the ''MDFI'' gene.
Function
This protein is a transcription factor that negatively regulates other myogenic family proteins. Studies of the mouse homolog, I-mf, show that it interf ...
,
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RGS5
Regulator of G-protein signaling 5 is a protein that in humans is encoded by the ''RGS5'' gene.
The regulator of G protein signaling (RGS) proteins are signal transduction molecules that have structural homology to SST2 of Saccharomyces cerevisia ...
,
and
*
RIC8A
Resistance to inhibitors of cholinesterase-8A (Ric-8A), also known as Synembryn-A, is a protein that in humans is encoded by the ''RIC8A'' gene.
Interactions
RIC8A has been shown to interact with GNAO1, GNA13, GNAQ, GNAS complex locus, GNAI2, GNA ...
.
References
Further reading
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{{GTPases