The GDNF family receptor-α (GFRα)

protein Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residue (biochemistry), residues. Proteins perform a vast array of functions within organisms, including Enzyme catalysis, catalysing metab ...

s are a group of

co-receptor A co-receptor is a cell surface receptor that binds a signalling molecule in addition to a primary receptor in order to facilitate Ligand (biochemistry), ligand recognition and initiate biological processes, such as entry of a pathogen into a host ...

s which form complexes with GDNF-family ligands (GFLs) to activate RET, the

receptor Receptor may refer to: * Sensory receptor, in physiology, any neurite structure that, on receiving environmental stimuli, produces an informative nerve impulse *Receptor (biochemistry), in biochemistry, a protein molecule that receives and respond ...

of the GFLs. The GFRα co-receptors include the following: * GFRα1 – preference for GDNF * GFRα2 – preference for neurturin * GFRα3 – preference for artemin * GFRα4 – preference for persephin * GFRAL - receptor for GDF15

References

{{DEFAULTSORT:GFRa TGFβ domain Proteins