Mannosyl-oligosaccharide glucosidase is an
enzyme that in humans is encoded by the ''MOGS''
gene.
Glucosidase I is the first enzyme in the N-linked oligosaccharide processing pathway. GCS1 cleaves the distal alpha-1,2-linked glucose residue from the Glc(3)-Man(9)-GlcNAc(2) oligosaccharide precursor. GCS1 is located in the lumen of the endoplasmic reticulum.
GCS1 may also refer to "generative cell specific 1", also called HAP2 (hapless2), a gene of lower
eukaryotes
Eukaryotes () are organisms whose cells have a nucleus. All animals, plants, fungi, and many unicellular organisms, are Eukaryotes. They belong to the group of organisms Eukaryota or Eukarya, which is one of the three domains of life. Bacte ...
which is thought to be responsible for
gametes fusion .
.
References
Further reading
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External links
GeneReviews/NCBI/NIH/UW entry on Congenital Disorders of Glycosylation Overview
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