GATA transcription factors are a family of

transcription factor In molecular biology, a transcription factor (TF) (or sequence-specific DNA-binding factor) is a protein that controls the rate of transcription of genetic information from DNA to messenger RNA, by binding to a specific DNA sequence. The fu ...

s characterized by their ability to bind to the DNA sequence "GATA". GATA transcription factors have been correlated to their broader influence on stem cell development. Findings however, have pointed to a more direct influence by GATA transcription factors, as they are salient components in the more concentrated regulation of gene expression. Data points to the roles GATA transcription factors play in stages past early development in endocrine organs. Despite GATA’s influence on endocrine organs and cell development, they have a complex relation to the development and growth of breast cancer. Its immediate influence is not yet known, its high risk for mutation however, makes determining the immediate influence of paramount importance in battling breast cancer.

Genes

In humans: *

GATA1 GATA-binding factor 1 or GATA-1 (also termed Erythroid transcription factor) is the founding member of the GATA family of transcription factors. This protein is widely expressed throughout vertebrate species. In humans and mice, it is encoded by ...

(see also ) *

GATA2 GATA2 or GATA-binding factor 2 is a transcription factor, i.e. a nuclear protein which regulates the expression of genes. It regulates many genes that are critical for the embryonic development, self-renewal, maintenance, and functionality of bl ...

(see also ) *

GATA3 GATA3 is a transcription factor that in humans is encoded by the ''GATA3'' gene. Studies in animal models and humans indicate that it controls the expression of a wide range of biologically and clinically important genes. The GATA3 transcription ...

(see also ) *

GATA4 Transcription factor GATA-4 is a protein that in humans is encoded by the ''GATA4'' gene. Function This gene encodes a member of the GATA family of zinc finger transcription factors. Members of this family recognize the GATA motif which is pr ...

(see also ) *

GATA5 Transcription factor GATA-5 is a protein that in humans is encoded by the ''GATA5'' gene. Function The protein encoded by this gene is a transcription factor that contains two GATA-type zinc fingers. The encoded protein is known to bind to hep ...

(see also ) *

GATA6 Transcription factor GATA-6, also known as GATA-binding factor 6 (GATA6), is protein that in humans is encoded by the ''GATA6'' gene. The gene product preferentially binds (A/T/C)GAT(A/T)(A) of the consensus binding sequence. Clinical significa ...

(see also ) In yeast: * GLN3 (see als
''GLN3''
* GAT1 (see als
''GAT1''
* DAL80 (see als
''DAL80''
* GZF3 (see als
''GZF3''

Bibliography

* Viger, Robert S; Guittot, Séverine Mazaud; Anttonen, Mikko; Wilson, David B; Heikinheimo, Markku (2008-04-01). "Role of the GATA Family of Transcription Factors in Endocrine Development, Function, and Disease". ''Molecular Endocrinology.'' ** This is a peer reviewed journal that covers the topic and will help establish notability. * Du, Feng; Yuan, Peng; Wang, Teng; Zhao, Jiuda; Zhao, Zitong; Luo, Yang; Xu, Binghe (2015-11). "The Significance and Therapeutic Potential of GATA3 Expression and Mutation in Breast Cancer: A Systematic Review". ''Medicinal Research Reviews''. ** This is a peer reviewed journal that covers the topic and will help establish notability.

References

External links

* Transcription factors Articles containing video clips {{biochem-stub