Growth arrest – specific 6, also known as GAS6, is a human
gene
In biology, the word gene (from , ; "... Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ''birth'' or ''gender'') can have several different meanings. The Mendelian gene is a b ...
coding for the GAS6 protein. It is similar to the
Protein S
Protein S (also known as PROS) is a vitamin K-dependent plasma glycoprotein synthesized in the liver. In the circulation, Protein S exists in two forms: a free form and a complex form bound to complement protein C4b-binding protein (C4BP). In huma ...
with the same domain organization and 43% amino acid identity. It was originally found as a gene upregulated by growth arrested fibroblasts.
Function
Gas6 is a
gamma-carboxyglutamic acid (Gla) domain-containing protein thought to be involved in the stimulation of cell proliferation.
Interactions
Gas6 has been shown to
interact
Advocates for Informed Choice, dba interACT or interACT Advocates for Intersex Youth, is a 501(c)(3) nonprofit organization using innovative strategies to advocate for the legal and human rights of children with intersex traits. The organizati ...
with
AXL receptor tyrosine kinase
Tyrosine-protein kinase receptor UFO is an enzyme that in humans is encoded by the ''AXL'' gene. The gene was initially designated as UFO, in allusion to the unidentified function of this protein. However, in the years since its discovery, resear ...
,
MerTK
Proto-oncogene tyrosine-protein kinase MER is an enzyme that in humans is encoded by the ''MERTK'' gene.
Function
This gene is a member of the TYRO3/AXL/MER (TAM) receptor kinase family and encodes a transmembrane protein with two fibronectin ...
and
TYRO3
Tyrosine-protein kinase receptor TYRO3 is an enzyme that in humans is encoded by the ''TYRO3'' gene.
Interactions
TYRO3 has been shown to interact with:
* GAS6, and
* PIK3R1
Phosphatidylinositol 3-kinase regulatory subunit alpha is an enzyme ...
.
The presence of Gla needs a
vitamin K
Vitamin K refers to structurally similar, fat-soluble vitamers found in foods and marketed as dietary supplements. The human body requires vitamin K for post-synthesis modification of certain proteins that are required for blood coagulation ...
-dependent enzymatic reaction that carboxylates the gamma carbon of certain glutamic residues of the protein during its production in the endoplasmic reticulum. The action of vitamin K is essential on GAS6 function.
References
Further reading
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
{{protein-stub