Gamma-aminobutyric acid B receptor, 1 (GABA
B1), is a
G-protein coupled receptor
G protein-coupled receptors (GPCRs), also known as seven-(pass)-transmembrane domain receptors, 7TM receptors, heptahelical receptors, serpentine receptors, and G protein-linked receptors (GPLR), form a large group of protein family, evolution ...
subunit encoded by the ''GABBR1''
gene
In biology, the word gene (from , ; "...Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ''birth'' or ''gender'') can have several different meanings. The Mendelian gene is a ba ...
.
Function
GABA
B1 is a receptor for
Gamma-aminobutyric acid. Upon binding, GABA
B1 will produce a slow and prolonged inhibitory effect. GABA
B1 is one part of a heterodimer, which is the GABA
B receptor, consisting of it and the related GABA
B2 protein. The GABA(B) receptor 1 gene is mapped to chromosome 6p21.3 within the HLA class I region close to the HLA-F gene. Susceptibility loci for multiple sclerosis, epilepsy, and schizophrenia have also been mapped in this region. Alternative splicing of this gene generates 4 transcript variants.
Interactions
GABBR1 has been shown to
interact
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with
ATF4 and
GABBR2
Gamma-aminobutyric acid (GABA) B receptor, 2 (GABAB2) is a G-protein coupled receptor subunit encoded by the GABBR2 gene in humans.
Function
B-type receptors for the neurotransmitter GABA (gamma-aminobutyric acid) inhibit neuronal activity thr ...
.
See also
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GABAB receptor
References
Further reading
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External links
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G protein-coupled receptors
{{transmembranereceptor-stub