FUJIFILM Diosynth Biotechnologies, abbreviated FDB and also referred to simply as Diosynth, is a biopharmaceutical

contract manufacturing organization A contract manufacturing organization (CMO), more recently referred to (and more commonly used now) as a contract development and manufacturing organization (CDMO) to avoid the acronym confusion of Chief Medical Officer or Clinical Monitoring Organ ...

that develops manufacturing processes and manufactures

active ingredient An active ingredient is any ingredient that provides biologically active or other direct effect in the diagnosis, cure, mitigation, treatment, or prevention of disease or to affect the structure or any function of the body of humans or animals. The ...

s and provides

fill and finish In the pharmaceutical industry, fill and finish (also referred to as fill finish, fill-finish or fill/finish) is the process of filling vials with vaccine , biological and pharmaceutical Drug Substances (DS) and finishing the process of packaging t ...

services for

pharmaceutical companies The pharmaceutical industry discovers, develops, produces, and markets drugs or pharmaceutical drugs for use as medications to be administered to patients (or self-administered), with the aim to cure them, vaccinate them, or alleviate symptoms. ...

. FUJIFILM Diosynth Biotechnologies is the world's second largest contract manufacturer of biopharmaceuticals, with manufacturing facilities in

Morrisville, North Carolina Morrisville is a town located primarily in Wake County, North Carolina, United States (a small portion extends into neighboring Durham County). The population was 18,576 at the 2010 census. The U.S. Census Bureau estimated the town's population t ...

and

College Station, Texas College Station is a city in Brazos County, Texas, Brazos County, Texas, situated in East-Central Texas in the heart of the Brazos Valley, towards the eastern edge of the region known as the Texas Triangle. It is northwest of Houston and east-n ...

in the United States, Teesside, United Kingdom and Hillerød, Denmark in Europe, and recently added sites in

Thousand Oaks, California Thousand Oaks is the second-largest city in Ventura County, California, United States. It is in the northwestern part of Greater Los Angeles, approximately from the city of Los Angeles and from Downtown. It is named after the many oak tr ...

and

Watertown, Massachusetts Watertown is a city in Middlesex County, Massachusetts, and is part of Greater Boston. The population was 35,329 in the 2020 census. Its neighborhoods include Bemis, Coolidge Square, East Watertown, Watertown Square, and the West End. Waterto ...

. FUJIFILM Diosynth Biotechnologies operates a highly automated multipurpose manufacturing facility in College Station, Texas under the federal government's Center for Innovation in Advanced Development and Manufacturing (CIADM) program, which is the largest scale-out cell culture manufacturing facility in the United States. In March 2021, the company announced that it had selected

Holly Springs, North Carolina Holly Springs is a town in Wake County, North Carolina, United States. As of the 2020 census, the town population was 41,239, a 67% increase from 2010. History Etymology The town's name refers to the free flowing springs that emerge into a ...

, located near its existing operations in Morrisville, for a $2 billion investment to establish a new large-scale cell culture production site, which is expected to be operational in 2025 and create 725 new jobs by the end of 2028. The company plans to install 8 x 20,000L bioreactors at the facility and plan for the ability to add an additional 24 x 20,000L bioreactors, as well as production lines for large scale automated fill and finish, labeling, and packaging services.

History

Early history

The company started in Oss,

Netherlands ) , anthem = ( en, "William of Nassau") , image_map = , map_caption = , subdivision_type = Sovereign state , subdivision_name = Kingdom of the Netherlands , established_title = Before independence , established_date = Spanish Netherl ...

in 1923 with the extraction of insulin from bovine pancreata, and porcine insulin extraction in 1930. In January 2005, the company became a part of

Organon The ''Organon'' ( grc, Ὄργανον, meaning "instrument, tool, organ") is the standard collection of Aristotle's six works on logical analysis and dialectic. The name ''Organon'' was given by Aristotle's followers, the Peripatetics. The six ...

, one of its sister companies in the

Akzo Nobel Akzo Nobel N.V., stylized as AkzoNobel, is a Dutch multinational company which creates paints and performance coatings for both industry and consumers worldwide. Headquartered in Amsterdam, the company has activities in more than 80 countrie ...

pharma group. Along with its sister companies Organon and

Intervet Merck & Co., Inc. is an American Multinational corporation, multinational pharmaceutical company headquartered in Rahway, New Jersey, and is named for Merck Group, founded in Germany in 1668, of whom it was once the American arm. The company doe ...

were sold to

Schering-Plough Schering-Plough Corporation was an American pharmaceutical company. It was originally the U.S. subsidiary of the German company Schering AG, which was founded in 1851 by Ernst Christian Friedrich Schering. As a result of nationalization, it beca ...

in March 2007 by

. Following the mergers of Schering-Plough with Merck & Co. (MSD) on March 9, 2009, the company temporarily became part of the MSD Nutritionals products company, belonging to the MSD group. In April 2011, the company was sold to

Fujifilm , trading as Fujifilm, or simply Fuji, is a Japanese multinational conglomerate headquartered in Tokyo, Japan, operating in the realms of photography, optics, office and medical electronics, biotechnology, and chemicals. The offerings from the ...

, forming Fujifilm Diosynth Biotechnologies. For most of the company's history, Diosynth manufactured biochemical substances and fine chemicals, with pharmaceutical raw materials coming largely from either animal origin or chemical intermediates. Under Fujifilm, it no longer focuses on small molecules, but instead develops processes for and mass manufactures biologics (e.g., proteins and mRNA). On December 18, 2014, Fujifilm Diosynth Biotechnologies acquired Kalon Biotherapeutic Technologies in College Station, TX, which became Fujifilm Diosynth Biotechnologies Texas. In March 2020, Fujifilm Diosynth Biotechnologies named Martin Meeson the company's new CEO. He will be taking over from Steve Bagshaw who is set to retire and become a non-executive chairman. Subject to regulatory approval, at least 60 million doses of the

Novavax COVID-19 vaccine The Novavax COVID-19 vaccine, sold under the brand names Nuvaxovid and Covovax, among others, is a subunit COVID-19 vaccine developed by Novavax and the Coalition for Epidemic Preparedness Innovations (CEPI). Full results from Nuvaxovid's p ...

will be manufactured for the UK government from 2021 by Fujifilm Diosynth Biotechnologies at its

Billingham Billingham is a town and civil parish in the Borough of Stockton-on-Tees, County Durham, England. The town is on the north side of the River Tees and is governed by Stockton-on-Tees Borough Council. The settlement had previously formed i ...

site.

References

{{Reflist Schering-Plough Companies based in New Jersey Companies based in North Brabant Oss