Fructose 6-phosphate (sometimes called the Neuberg ester) is a derivative of

fructose Fructose, or fruit sugar, is a ketonic simple sugar found in many plants, where it is often bonded to glucose to form the disaccharide sucrose. It is one of the three dietary monosaccharides, along with glucose and galactose, that are absorb ...

, which has been

phosphorylated In chemistry, phosphorylation is the attachment of a phosphate group to a molecule or an ion. This process and its inverse, dephosphorylation, are common in biology and could be driven by natural selection. Text was copied from this source, wh ...

at the 6-hydroxy group. It is one of several possible

fructosephosphate Fructosephosphates are sugar phosphates based upon fructose, and are common in the biochemistry of cells. Fructosephosphates play integral roles in many metabolic pathways, particularly glycolysis, gluconeogenesis and the pentose phosphate pathwa ...

s. The β-D-form of this compound is very common in

cells Cell most often refers to: * Cell (biology), the functional basic unit of life Cell may also refer to: Locations * Monastic cell, a small room, hut, or cave in which a religious recluse lives, alternatively the small precursor of a monastery w ...

. The great majority of

glucose Glucose is a simple sugar with the molecular formula . Glucose is overall the most abundant monosaccharide, a subcategory of carbohydrates. Glucose is mainly made by plants and most algae during photosynthesis from water and carbon dioxide, u ...

is converted to fructose 6-phosphate upon entering a cell.

Fructose Fructose, or fruit sugar, is a ketonic simple sugar found in many plants, where it is often bonded to glucose to form the disaccharide sucrose. It is one of the three dietary monosaccharides, along with glucose and galactose, that are absorb ...

is predominantly converted to fructose 1-phosphate by fructokinase following cellular import.

History

The name ''Neuberg ester'' comes from the German biochemist Carl Neuberg. In 1918, he found that the compound (later identified as fructose 6-phosphate) was beproduced by mild acid hydrolysis of fructose 2,6-bisphosphate.Fruton, Joseph S. ''Proteins, Enzymes, Genes: The Interplay of Chemistry and Biology''. Yale University Press: New Haven, 1999. p 292

In glycolysis

Fructose 6-phosphate lies within the

glycolysis Glycolysis is the metabolic pathway that converts glucose () into pyruvate (). The free energy released in this process is used to form the high-energy molecules adenosine triphosphate (ATP) and reduced nicotinamide adenine dinucleotide (NADH ...

metabolic pathway In biochemistry, a metabolic pathway is a linked series of chemical reactions occurring within a cell. The reactants, products, and intermediates of an enzymatic reaction are known as metabolites, which are modified by a sequence of chemical ...

and is produced by isomerisation of glucose 6-phosphate. It is in turn further phosphorylated to fructose-1,6-bisphosphate.

References

{{DEFAULTSORT:Fructosephosphate6 Monosaccharide derivatives Organophosphates Phosphate esters Glycolysis

History

In glycolysis

See also

References