Francisco Ayala may refer to:
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Francisco Ayala (novelist) (1906–2009), Spanish novelist
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Francisco J. Ayala
Francisco José Ayala Pereda (born March 12, 1934) is a Spanish-American evolutionary biologist, philosopher, and former Catholic priest who was a longtime faculty member at the University of California, Irvine and University of California, Dav ...
(born 1934), Spanish-American biologist and philosopher
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Francisco Ayala (footballer) (born 1989), Chilean footballer
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