Fumarylacetoacetic acid (fumarylacetoacetate) is an intermediate in the metabolism of
tyrosine
-Tyrosine or tyrosine (symbol Tyr or Y) or 4-hydroxyphenylalanine is one of the 20 standard amino acids that are used by cells to synthesize proteins. It is a non-essential amino acid with a polar side group. The word "tyrosine" is from the Gr ...
. It is formed through the conversion of
maleylacetoacetate
4-Maleylacetoacetate (4-maleylacetoacetatic acid) is an intermediate in the metabolism of tyrosine. It is converted to fumarylacetoacetate by the enzyme 4-maleylacetoacetate cis-trans-isomerase. Gluthathione coenzymatically helps in conversion to ...
into fumarylacetoacetate by the enzyme
maleylacetoacetate isomerase.
See also
*
Fumarylacetoacetate hydrolase
Fumarylacetoacetase is an enzyme that in humans is encoded by the ''FAH'' gene located on chromosome 15. The FAH gene is thought to be involved in the catabolism of the amino acid phenylalanine in humans.
Function
Fumarylacetoacetate hydrolase ( ...
References
Dicarboxylic acids
Beta-keto acids
Enones
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