Fráter–Seebach Alkylation on:
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In organic chemistry, the Fráter–Seebach alkylation (also known as Seebach–Fráter alkylation or Fráter–Seebach reaction) is a diastereoselective alkylation of chiral beta-hydroxy esters using strong bases. The reaction was first published by Georg Fráter in 1979; in 1980,
An alkylating agent (
This reaction has since been used in the synthesis of many natural products due to its high yield and diastereoselectivity.
Dieter Seebach
Dieter Seebach is a German chemist known for his synthesis of biopolymers and dendrimers, and for his contributions to stereochemistry. He was born on 31 October 1937 in Karlsruhe. He studied chemistry at the University of Karlsruhe (TH) under th ...
reported about a similar reaction with malic acid ester.
Outline and mechanism
Chiral beta-hydroxy esters can be treated with two equivalents of a strong base ( lithium diisopropylamide (LDA) or lithium bis(trimethylsilyl)amide (LHMDS) are popular choices) to both remove the proton on the alcohol and enolize the ester.
An alkylating agent (methyl iodide
Iodomethane, also called methyl iodide, and commonly abbreviated "MeI", is the chemical compound with the formula CH3I. It is a dense, colorless, volatile liquid. In terms of chemical structure, it is related to methane by replacement of one h ...
in the case of Fráter's publication) is then added. This attacks from the opposite face of the chiral hydroxyl group to avoid steric hindrance as shown below in the 6-membered transition state with chelating metal ions.
This reaction has since been used in the synthesis of many natural products due to its high yield and diastereoselectivity.
References
{{DEFAULTSORT:Frater-Seebach alkylation Name reactions