Fructoselysine-6-kinase (sometimes also called fructoselysine kinase) is a

kinase In biochemistry, a kinase () is an enzyme that catalyzes the transfer of phosphate groups from high-energy, phosphate-donating molecules to specific substrates. This process is known as phosphorylation, where the high-energy ATP molecule don ...

enzyme Enzymes () are proteins that act as biological catalysts by accelerating chemical reactions. The molecules upon which enzymes may act are called substrates, and the enzyme converts the substrates into different molecules known as products. A ...

. It phosphorylates

fructoselysine Fructoselysine is an Amadori adduct of glucose to lysine. It breaks down into furosine on acid-catalysed hydrolysis. ''E. coli'' breaks it down using the enzymes fructoselysine-6-kinase and fructoselysine 6-phosphate deglycase into glucose 6- ...

on the

fructose Fructose, or fruit sugar, is a Ketose, ketonic monosaccharide, simple sugar found in many plants, where it is often bonded to glucose to form the disaccharide sucrose. It is one of the three dietary monosaccharides, along with glucose and galacto ...

residue's 6-carbon to form fructoselysine-6-phosphate, as the first step to breaking it down to

glucose-6-phosphate Glucose 6-phosphate (G6P, sometimes called the Robison ester) is a glucose sugar phosphorylated at the hydroxy group on carbon 6. This dianion is very common in cells as the majority of glucose entering a cell will become phosphorylated in this wa ...

and

lysine Lysine (symbol Lys or K) is an α-amino acid that is a precursor to many proteins. It contains an α-amino group (which is in the protonated form under biological conditions), an α-carboxylic acid group (which is in the deprotonated −C ...

for use as a food source. The second step is accomplished by the enzyme fructoselysine-6-phosphate deglycase. In ''

E. coli ''Escherichia coli'' (),Wells, J. C. (2000) Longman Pronunciation Dictionary. Harlow ngland Pearson Education Ltd. also known as ''E. coli'' (), is a Gram-negative, facultative anaerobic, rod-shaped, coliform bacterium of the genus ''Escher ...

'', both enzymes are located on the ''frl'' (fructoselysine) operon in order to be transcribed simultaneously. In this context it is known as gene 'frlD' and fructoselysine 6-phosphate deglycase as 'frlB'.

References

External links

Ecocyc

UniProt
als
Q6IFZ3

Pubmed
Enzymes {{Enzyme-stub