Fred Saul Rosen (May 25, 1930 – May 21, 2005) was a

pediatrician Pediatrics ( also spelled ''paediatrics'' or ''pædiatrics'') is the branch of medicine that involves the medical care of infants, children, adolescents, and young adults. In the United Kingdom, paediatrics covers many of their youth until the ...

and immunologist at

Harvard Medical School Harvard Medical School (HMS) is the graduate medical school of Harvard University and is located in the Longwood Medical Area of Boston, Massachusetts. Founded in 1782, HMS is one of the oldest medical schools in the United States and is consi ...

and Boston Children's Hospital.

Early life and career

Rosen was born in

Newark, NJ Newark ( , ) is the most populous city in the U.S. state of New Jersey and the seat of Essex County and the second largest city within the New York metropolitan area.Lafayette College and his MD from

Case Western Reserve University Case Western Reserve University (CWRU) is a private research university in Cleveland, Ohio. Case Western Reserve was established in 1967, when Western Reserve University, founded in 1826 and named for its location in the Connecticut Western Reser ...

. He moved to Boston in 1955 to begin a

pathology Pathology is the study of the causes and effects of disease or injury. The word ''pathology'' also refers to the study of disease in general, incorporating a wide range of biology research fields and medical practices. However, when used in ...

residency at Children's where he worked with

Charles Janeway Charles Alderson Janeway, Jr. (1943–2003) was a noted immunologist who helped create the modern field of innate immunity. A member of the National Academy of Sciences, he held a faculty position at Yale University's Medical School and was ...

and Sidney Farber. He began an immunology fellowship in 1959. He and Janeway pioneered the study of primary immunodeficiency diseases at Boston Children's Hospital. Rosen discovered, early in his career, the cause of X-linked hyper-

IgM Immunoglobulin M (IgM) is one of several isotypes of antibody (also known as immunoglobulin) that are produced by vertebrates. IgM is the largest antibody, and it is the first antibody to appear in the response to initial exposure to an antig ...

syndrome. He also worked on X-linked

agammaglobulinaemia Hypogammaglobulinemia is a problem with the immune system in which not enough gamma globulins are produced in the blood (thus '' hypo-'' + ''gamma'' + ''globulin'' + '' -emia''). This results in a lower antibody count, which impairs the immune sys ...

. He published over 300 papers on his research. Rosen was the head of the division of immunology at Boston Children's Hospital from 1968 to 1985. In 1987, he moved to the CBR Institute for Biomedical Research at

Harvard University Harvard University is a private Ivy League research university in Cambridge, Massachusetts. Founded in 1636 as Harvard College and named for its first benefactor, the Puritan clergyman John Harvard, it is the oldest institution of higher le ...

. Rosen spoke French, Italian Spanish, German, Italian, Arabic and Russian, and traveled extensively. Rosen died of cancer in 2005. He had no surviving family members.

References

{{DEFAULTSORT:Rosen, Fred S. 1930 births 2005 deaths Harvard Medical School faculty American pediatricians American immunologists Members of the National Academy of Medicine