Frank J. Rauscher III, Ph.D. was a researcher at The Wistar Institute in

Philadelphia Philadelphia, often called Philly, is the largest city in the Commonwealth of Pennsylvania, the sixth-largest city in the U.S., the second-largest city in both the Northeast megalopolis and Mid-Atlantic regions after New York City. Sinc ...

. Rauscher is also a professor of genetics at the

University of Pennsylvania School of Medicine The Perelman School of Medicine, commonly known as Penn Med, is the medical school of the University of Pennsylvania, a private research university in Philadelphia, Pennsylvania. Founded in 1765, the Perelman School of Medicine is the oldest medi ...

. He graduated from

Moravian College Moravian University is a private university in Bethlehem, Pennsylvania. The institution traces its founding to 1742 by Moravians, descendants of followers of the Bohemian Reformation under John Amos Comenius. Founded in 1742, Moravian University ...

in 1979. His research focuses on mechanisms responsible for gene silencing during development and homeostasis and disruptions associated with the initiation of tumors. When Rauscher first arrived at Wistar, one of his research priorities was the tumor suppressor gene

wt1 Wilms tumor protein (WT33) is a protein that in humans is encoded by the ''WT1'' gene on chromosome 11p. Function This gene encodes a transcription factor that contains four zinc finger motifs at the C-terminus and a proline / glutamine-rich ...

and its role in the development of

Wilms' tumor Wilms' tumor or Wilms tumor, also known as nephroblastoma, is a cancer of the kidneys that typically occurs in children, rarely in adults.; and occurs most commonly as a renal tumor in child patients. It is named after Max Wilms, the German surg ...

. Rauscher's research found that if wt1 is mutated, cells of the kidney might continue to grow out of control. Rauscher is the former editor-in-chief of the journal ''

Cancer Research Cancer research is research into cancer to identify causes and develop strategies for prevention, diagnosis, treatment, and cure. Cancer research ranges from epidemiology, molecular bioscience to the performance of clinical trials to evaluate and ...

''. He is the son of Frank J. Rauscher, Jr., former director of the

National Cancer Institute The National Cancer Institute (NCI) coordinates the United States National Cancer Program and is part of the National Institutes of Health (NIH), which is one of eleven agencies that are part of the U.S. Department of Health and Human Services. ...

Select publications

* Iyengar S, Ivanov AV, Jin VX, Rauscher FJ 3rd, Farnham PJ., Functional analysis of KAP1 genomic recruitment., Molecular and Cellular Biology. 2011 May;31(9):1833-47. * Mellert HSA, Stanek TJ, Sykes SM, Rauscher FJ, Schultz DC, McMahon SB., Deacetylation of the DNA-binding domain regulates p53-mediated apoptosis., Journal of Biological Chemistry. 2011 Feb 11;286(6):4264-70. * Negorev DG, Vladimirova OV, Kossenkov AV, Nikonova EV, Demarest RM, Capobianco AJ, Showe MK, Rauscher FJ, Showe LC, Maul GG., Sp 100 as a potent tumor suppressor: accelerated senescence and rapid malignant transformation of human fibroblasts through modulation of an embryonic stem cell program., Cancer Research. 2010 Dec 1;70(23):9991-10001. * Yu H, Mashtalir N, Daou S, Hammond-Martel I, Ross J, Sui G, Hart GW, Rauscher FJ 3rd, Drobetsky E, Milot E, Shi Y, Affar EB., The ubiquitin carboxyl hydrolase BAP1 forms a ternary complex with YY! and HCF-1 and is a critical regulator of gene expression., Molecular and Cellular Biology. 2010 Nov;30(21):5071-85. * Hou Z, Peng H, White DE, Wang P, Lieberman PM, Halazonetis T, Rauscher FJ3rd., 14-3-3 binding sites in the snail protein are essential for snail-mediated transcriptional repression and epithelial-mesenchymal differentiation., Cancer Research. 2010 Jun 1;70(11):4385-93. pub 2010 May 25Erratum in: Cancer Res. 2010 Sep 1;70(17):7012-3.

References

External links

Dr. Rauscher's lab page on The Wistar Institute's website
{{DEFAULTSORT:Rauscher, Frank III Cancer researchers Living people Moravian University alumni University at Buffalo alumni Year of birth missing (living people)