Francisco Hernández may refer to:
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Francisco Hernández de Toledo (1514–1587), naturalist and court physician to the King of Spain
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Francisco Hernández de Córdoba (founder of Nicaragua) :''There were two Spanish '' conquistadores'' at the start of the 16th-century named Francisco Hernández de Córdoba. The one described here founded Nicaragua. The other led a 1517 expedition which provided the first European accounts of the Yucatà ...
(c. 1475–1526)
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Francisco Hernández de Córdoba (Yucatán conquistador) (died 1517), Spanish conquistador
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Francisco Hernández Ortiz-Pizarro (1555–1613), founder of Fort Calbuco
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Francisco Hernández (footballer, born 1949) (1949–2019), football player from Costa Rica
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Francisco Hernández (Mexican footballer) (1924–2011), player who competed at the FIFA World Cup
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Francisco Hernández Tomé (died 1872), Spanish mural painter
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Francisco Jose Hernandez (born 1936), Cuban exile and president of the Cuban American National Foundation
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Francisco Hernández (rugby union) (born 1988), Spanish rugby sevens player
{{hndis, Hernandez, Francisco