Fluorenylmethyloxycarbonyl chloride (Fmoc-Cl) is a

chloroformate Chloroformates are a class of organic compounds with the formula ROC(O)Cl. They are formally esters of chloroformic acid. Most are colorless, volatile liquids that degrade in moist air. A simple example is methyl chloroformate, which is commer ...

ester. It is used to introduce the

fluorenylmethyloxycarbonyl protecting group The fluorenylmethoxycarbonyl protecting group (Fmoc) is a base-labile protecting group used in organic synthesis. Protection & Formation Fmoc carbamate is frequently used as a protecting group for amines, where the Fmoc group can be introduced by ...

as the Fmoc carbamate.

Preparation

This compound may be prepared by reacting 9-fluorenylmethanol with phosgene: : Preparation of Fmoc-Cl

References

{{reflist Chloroformates Reagents for organic chemistry Reagents for biochemistry Biochemistry methods