Fluorenylmethyloxycarbonyl chloride (Fmoc-Cl) is a
chloroformate
Chloroformates are a class of organic compounds with the formula ROC(O)Cl. They are formally esters of chloroformic acid. Most are colorless, volatile liquids that degrade in moist air. A simple example is methyl chloroformate, which is commer ...
ester. It is used to introduce the
fluorenylmethyloxycarbonyl protecting group
The fluorenylmethoxycarbonyl protecting group (Fmoc) is a base-labile protecting group used in organic synthesis.
Protection & Formation
Fmoc carbamate is frequently used as a protecting group for amines, where the Fmoc group can be introduced by ...
as the Fmoc
carbamate.
Preparation
This compound may be prepared by reacting
9-fluorenylmethanol with
phosgene:
:
References
{{reflist
Chloroformates
Reagents for organic chemistry
Reagents for biochemistry
Biochemistry methods