Fluorenylmethyloxycarbonyl chloride (Fmoc-Cl) is a
chloroformate
Chloroformates are a class of organic compounds with the formula ROC(O)Cl. They are formally esters of chloroformic acid. Most are colorless, volatile liquids that degrade in moist air. A simple example is methyl chloroformate, which is commer ...
ester. It is used to introduce the
fluorenylmethyloxycarbonyl protecting group
The fluorenylmethoxycarbonyl protecting group (Fmoc) is a base-labile protecting group used in organic synthesis.
Protection & Formation
Fmoc carbamate is frequently used as a protecting group for amines, where the Fmoc group can be introduced by ...
as the Fmoc
carbamate
In organic chemistry, a carbamate is a category of organic compounds with the general formula and structure , which are formally derived from carbamic acid (). The term includes organic compounds (e.g., the ester ethyl carbamate), formally o ...
.
Preparation
This compound may be prepared by reacting
9-fluorenylmethanol with
phosgene
Phosgene is the organic chemical compound with the formula COCl2. It is a toxic, colorless gas; in low concentrations, its musty odor resembles that of freshly cut hay or grass. Phosgene is a valued and important industrial building block, espe ...
:
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References
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Chloroformates
Reagents for organic chemistry
Reagents for biochemistry
Biochemistry methods