Flumetasone, also known as flumethasone, is a

corticosteroid Corticosteroids are a class of steroid hormones that are produced in the adrenal cortex of vertebrates, as well as the synthetic analogues of these hormones. Two main classes of corticosteroids, glucocorticoids and mineralocorticoids, are involv ...

for topical use. It was patented in 1951 and approved for medical use in 1964.

Chemistry

Flumethasone is 420 times as potent as cortisone in an animal model for anti-inflammatory activity.

Names

Trade names include Locacorten, Locorten, and Orsalin. It is available in combination with

clioquinol Clioquinol (iodochlorhydroxyquin) is an antifungal drug and antiprotozoal drug. It is neurotoxic in large doses. It is a member of a family of drugs called hydroxyquinolines which inhibit certain enzymes related to DNA replication. The drugs h ...

, under the trade name Locacorten-Vioform (in some countries Locorten-Vioform), for the treatment of

otitis externa Otitis externa, also called swimmer's ear, is inflammation of the ear canal. It often presents with ear pain, swelling of the ear canal, and occasionally decreased hearing. Typically there is pain with movement of the outer ear. A high fever is ...

and

otomycosis Otomycosis is a fungal ear infection, a superficial mycotic infection of the outer ear canal. It is more common in tropical countries. The infection may be either subacute or acute and is characterized by malodorous discharge, inflammation, pru ...

. It is usually formulated as the

pivalic acid Pivalic acid is a carboxylic acid with a molecular formula of (CH3)3CCO2H. This colourless, odiferous organic compound is solid at room temperature. A common abbreviation for the pivalyl or pivaloyl group (''t''-BuC(O)) is Piv and for pivalic acid ...

ester In chemistry, an ester is a compound derived from an oxoacid (organic or inorganic) in which at least one hydroxyl group () is replaced by an alkoxy group (), as in the substitution reaction of a carboxylic acid and an alcohol. Glycerides ar ...

prodrug A prodrug is a medication or compound that, after intake, is metabolized (i.e., converted within the body) into a pharmacologically active drug. Instead of administering a drug directly, a corresponding prodrug can be used to improve how the drug ...

called

flumetasone pivalate Flumetasone pivalate is a synthetic glucocorticoid corticosteroid and a corticosteroid ester. It is the 21-acetate ester of flumetasone Flumetasone, also known as flumethasone, is a corticosteroid for topical use. It was patented in 1951 ...

References

Glucocorticoids Organofluorides {{dermatologic-drug-stub

Chemistry

Names

See also

References