Flavokavain B is a
flavokavain found in the
kava plant.
In 2010 a paper was published identifying it as a glutathione-depleting
hepatotoxin
A hepatotoxin ('' Gr., hepato = liver'') is a toxic chemical substance that damages the liver.
It can be a side-effect, but hepatotoxins are also found naturally, such as microcystins and pyrrolizidine alkaloids, or in laboratory environments, su ...
.
[Zhou P., Gross S., Liu J.-H., Yu B.-Y., Feng L.-L., Nolta J., Sharma V., Piwnica-Worms D., Qiu S.X 'Flavokawain B, the hepatotoxic constituent from kava root, induces GSH-sensitive oxidative stress through modulation of IKK/NF-κB and MAPK signaling pathways . FASEB Journal 2010 24:12 (4722-4732)]
FKB is said by enthusiasts to occur at higher concentrations in "tudei" kava strains, which are generally considered less desirable.
See also
*
Kavalactone
References
External links
Flavokawain Bat the ''
United States National Library of Medicine
The United States National Library of Medicine (NLM), operated by the United States federal government, is the world's largest medical library.
Located in Bethesda, Maryland, the NLM is an institute within the National Institutes of Health. Its ...
''
Kava
Phenol ethers
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