''Fig mosaic emaravirus'' (FMV) is a segmented,
negative sense, single-stranded
RNA virus
An RNA virus is a virusother than a retrovirusthat has ribonucleic acid (RNA) as its genetic material. The nucleic acid is usually single-stranded RNA ( ssRNA) but it may be double-stranded (dsRNA). Notable human diseases caused by RNA viruses ...
that is determined to be the causal agent of fig mosaic disease (FMD) in fig plants, ''
Ficus carica
The fig is the edible fruit of ''Ficus carica'', a species of small tree in the flowering plant family Moraceae. Native to the Mediterranean and western Asia, it has been cultivated since ancient times and is now widely grown throughout the world ...
''.
It is a member of the genus ''
Emaravirus
''Emaravirus'' is a genus of negative-strand RNA viruses which infect plants. The plant virus group is the sole genus in the family ''Fimoviridae''. The genus has 21 species.
Structure
Virions of this genus are between 80 and 100 nm and co ...
'' and order ''
Bunyavirales
''Bunyavirales'' is an order of segmented negative-strand RNA viruses with mainly tripartite genomes. Member viruses infect arthropods, plants, protozoans, and vertebrates. It is the only order in the class ''Ellioviricetes''. The name ''Bunyavir ...
'' and is transmitted mainly by the
eriophyid
Eriophyidae is a family of more than 200 genera of mites, which live as plant parasites, commonly causing galls or other damage to the plant tissues and hence known as gall mites. About 3,600 species have been described, but this is probably ...
mite ''Aceria ficus''.
FMV can cause a range of symptoms varying in severity, including leaf
chlorosis
In botany, chlorosis is a condition in which leaves produce insufficient chlorophyll. As chlorophyll is responsible for the green color of leaves, chlorotic leaves are pale, yellow, or yellow-white. The affected plant has little or no ability to ...
, deformity, and mosaic or discoloration patterns, as well as premature fruit drop.
History
Fig mosaic disease (FMD) was first
described and suspected to be of viral origin in 1933 by
Ira J. Condit and
W.T.Horne.
It was determined to be caused by a virus in 2009 by
Jeewan Jyot Walia,
Nida M. Salem Nida or NIDA may refer to:
People
* Nida Allam (born 1993), American politician
* Nida Fazli (1938–2016), Indian Hindi and Urdu poet and lyricist
* Nida Eliz Üstündağ (born 1996), Turkish female swimmer
* Eugene Nida (1914–2011), American ...
, and
Bryce W. Falk.
The disease and associated virus have since been observed in
Greece
Greece,, or , romanized: ', officially the Hellenic Republic, is a country in Southeast Europe. It is situated on the southern tip of the Balkans, and is located at the crossroads of Europe, Asia, and Africa. Greece shares land borders with ...
,
Italy
Italy ( it, Italia ), officially the Italian Republic, ) or the Republic of Italy, is a country in Southern Europe. It is located in the middle of the Mediterranean Sea, and its territory largely coincides with the homonymous geographical re ...
,
Spain
, image_flag = Bandera de España.svg
, image_coat = Escudo de España (mazonado).svg
, national_motto = ''Plus ultra'' (Latin)(English: "Further Beyond")
, national_anthem = (English: "Royal March")
, i ...
,
Turkey
Turkey ( tr, Türkiye ), officially the Republic of Türkiye ( tr, Türkiye Cumhuriyeti, links=no ), is a list of transcontinental countries, transcontinental country located mainly on the Anatolia, Anatolian Peninsula in Western Asia, with ...
,
Syria
Syria ( ar, سُورِيَا or سُورِيَة, translit=Sūriyā), officially the Syrian Arab Republic ( ar, الجمهورية العربية السورية, al-Jumhūrīyah al-ʻArabīyah as-Sūrīyah), is a Western Asian country loc ...
,
Tunisia
)
, image_map = Tunisia location (orthographic projection).svg
, map_caption = Location of Tunisia in northern Africa
, image_map2 =
, capital = Tunis
, largest_city = capital
, ...
,
Algeria
)
, image_map = Algeria (centered orthographic projection).svg
, map_caption =
, image_map2 =
, capital = Algiers
, coordinates =
, largest_city = capital
, relig ...
,
Jordan
Jordan ( ar, الأردن; tr. ' ), officially the Hashemite Kingdom of Jordan,; tr. ' is a country in Western Asia. It is situated at the crossroads of Asia, Africa, and Europe, within the Levant region, on the East Bank of the Jordan Rive ...
,
New Zealand
New Zealand ( mi, Aotearoa ) is an island country in the southwestern Pacific Ocean. It consists of two main landmasses—the North Island () and the South Island ()—and over 700 smaller islands. It is the sixth-largest island count ...
,
China
China, officially the People's Republic of China (PRC), is a country in East Asia. It is the world's most populous country, with a population exceeding 1.4 billion, slightly ahead of India. China spans the equivalent of five time zones and ...
,
Great Britain
Great Britain is an island in the North Atlantic Ocean off the northwest coast of continental Europe. With an area of , it is the largest of the British Isles, the largest European island and the ninth-largest island in the world. It is ...
,
Puerto Rico
Puerto Rico (; abbreviated PR; tnq, Boriken, ''Borinquen''), officially the Commonwealth of Puerto Rico ( es, link=yes, Estado Libre Asociado de Puerto Rico, lit=Free Associated State of Puerto Rico), is a Caribbean island and Unincorporated ...
,
Australia
Australia, officially the Commonwealth of Australia, is a Sovereign state, sovereign country comprising the mainland of the Australia (continent), Australian continent, the island of Tasmania, and numerous List of islands of Australia, sma ...
, and the
United States
The United States of America (U.S.A. or USA), commonly known as the United States (U.S. or US) or America, is a country primarily located in North America. It consists of 50 states, a federal district, five major unincorporated territorie ...
.
Classification
FMV has been placed in the genus ''Emaravirus'',
which contains other single-stranded, negative-sense, segmented RNA plant viruses. Emaraviruses all contain four to six
genome
In the fields of molecular biology and genetics, a genome is all the genetic information of an organism. It consists of nucleotide sequences of DNA (or RNA in RNA viruses). The nuclear genome includes protein-coding genes and non-coding ge ...
segments. They are also common in their mode of transmission, which is via various species of
eriophyid mites by unknown mechanism as well as mechanical modes of transmission.
Besides FMV, the genus ''Emaravirus'' includes ''
European mountain ash ringspot-associated emaravirus
European, or Europeans, or Europeneans, may refer to:
In general
* ''European'', an adjective referring to something of, from, or related to Europe
** Ethnic groups in Europe
** Demographics of Europe
** European cuisine, the cuisines of Europe a ...
'' (EMARaV), ''
Rose rosette emaravirus
''Rose rosette emaravirus'' (RRV) is a negative sense RNA virus species of virus in the order Bunyavirales. It is known to infect rose
A rose is either a woody perennial flowering plant of the genus ''Rosa'' (), in the family Rosaceae () ...
'' (RRV), ''
Raspberry leaf blotch emaravirus
The raspberry is the edible fruit of a multitude of plant species in the genus ''Rubus'' of the rose family, most of which are in the subgenus '' Idaeobatus''. The name also applies to these plants themselves. Raspberries are perennial with ...
'' (RLBV), and other species.
Genome Structure
The FMV genome consists of segmented (multipartite)
negative-sense, single-stranded RNA.
The genome has long been thought to have four segments, but recent findings have supported the existence of six RNA genome segments.
Each segment has one
open reading frame
In molecular biology, open reading frames (ORFs) are defined as spans of DNA sequence between the start and stop codons. Usually, this is considered within a studied region of a prokaryotic DNA sequence, where only one of the six possible readin ...
(ORF).
The first segment, FMV vcRNA 1 (7093 nt), is common to all viruses of genus ''Emaravirus'' and codes for the virus's 264
kDa
The dalton or unified atomic mass unit (symbols: Da or u) is a non-SI unit of mass widely used in physics and chemistry. It is defined as of the mass of an unbound neutral atom of carbon-12 in its nuclear and electronic ground state and at re ...
RNA-dependent RNA polymerase
RNA-dependent RNA polymerase (RdRp) or RNA replicase is an enzyme that catalyzes the replication of RNA from an RNA template. Specifically, it catalyzes synthesis of the RNA strand complementary to a given RNA template. This is in contrast to t ...
(RdRp), which has
endonuclease
Endonucleases are enzymes that cleave the phosphodiester bond within a polynucleotide chain. Some, such as deoxyribonuclease I, cut DNA relatively nonspecifically (without regard to sequence), while many, typically called restriction endonucleases ...
activity near the
N-terminus
The N-terminus (also known as the amino-terminus, NH2-terminus, N-terminal end or amine-terminus) is the start of a protein or polypeptide, referring to the free amine group (-NH2) located at the end of a polypeptide. Within a peptide, the ami ...
. The second segment, vcRNA2, (2252 nt) encodes a 73 kDa