Fedotozine (
INN
Inns are generally establishments or buildings where travelers can seek lodging, and usually, food and drink. Inns are typically located in the country or along a highway; before the advent of motorized transportation they also provided accommo ...
; JO 1196 for the (-) tartrate salt) is an
opioid
Opioids are substances that act on opioid receptors to produce morphine-like effects. Medically they are primarily used for pain relief, including anesthesia. Other medical uses include suppression of diarrhea, replacement therapy for opioid us ...
drug
A drug is any chemical substance that causes a change in an organism's physiology or psychology when consumed. Drugs are typically distinguished from food and substances that provide nutritional support. Consumption of drugs can be via insuffla ...
of the
arylacetamide series which acts as a
peripherally specific selective Îș1-opioid receptor agonist
An agonist is a chemical that activates a receptor to produce a biological response. Receptors are cellular proteins whose activation causes the cell to modify what it is currently doing. In contrast, an antagonist blocks the action of the ago ...
with preference for the Îș
1A subtype.
It was under investigation for the treatment of
gastrointestinal conditions like
irritable bowel syndrome and
functional dyspepsia
Indigestion, also known as dyspepsia or upset stomach, is a condition of impaired digestion. Symptoms may include upper abdominal fullness, heartburn, nausea, belching, or upper abdominal pain. People may also experience feeling full earlier t ...
and made it to
phase III clinical trial
Clinical trials are prospective biomedical or behavioral research studies on human participants designed to answer specific questions about biomedical or behavioral interventions, including new treatments (such as novel vaccines, drugs, dietar ...
s,
but ultimately development was discontinued and it was never marketed.
See also
*
Asimadoline
Asimadoline (EMD-61753) is an experimental drug which acts as a peripherally selective Îș-opioid receptor (KOR) agonist. Because of its low penetration across the bloodâbrain barrier, asimadoline lacks the psychotomimetic effects of centrally ...
*
Trimebutine
Trimebutine is a drug with antimuscarinic and weak mu opioid agonist effects. It is used for the treatment of irritable bowel syndrome and other gastrointestinal disorders.
The major product from drug metabolism of trimebutine in human beings ...
References
{{Opioidergics
Acetamides
Analgesics
Kappa-opioid receptor agonists
Opioids
Peripherally selective drugs
Abandoned drugs