Frederick of Sicily may refer to:
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Frederick II, Holy Roman Emperor
Frederick II (German language, German: ''Friedrich''; Italian language, Italian: ''Federico''; Latin: ''Federicus''; 26 December 1194 – 13 December 1250) was King of Sicily from 1198, King of Germany from 1212, King of Italy and Holy Roman Em ...
(1194-1250), also known as Frederick I of Sicily
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Frederick III of Sicily (1272-1337), self-styled the third despite being the second Frederick to rule Sicily (Trinacria)
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Frederick the Simple (1341-1377), third Frederick to rule Sicily (Trinacria)
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Frederick IV of Naples (1452-1504), continued Neapolitan claim to Kingdom of Sicily
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