3-dehydrosphinganine reductase () also known as 3-ketodihydrosphingosine reductase (KDSR) or follicular variant translocation protein 1 (FVT1) is an
enzyme that in humans is encoded by the ''KDSR''
gene.
Function
3-dehydrosphinganine reductase
catalyzes
Catalysis () is the process of increasing the rate of a chemical reaction by adding a substance known as a catalyst (). Catalysts are not consumed in the reaction and remain unchanged after it. If the reaction is rapid and the catalyst recyc ...
the
chemical reaction:
:sphinganine + NADP
+ 3-dehydrosphinganine + NADPH + H
+
Thus, the two
substrates of this enzyme are
sphinganine and
NADP+, whereas its 3
products are
3-dehydrosphinganine,
NADPH
Nicotinamide adenine dinucleotide phosphate, abbreviated NADP or, in older notation, TPN (triphosphopyridine nucleotide), is a cofactor used in anabolic reactions, such as the Calvin cycle and lipid and nucleic acid syntheses, which require NAD ...
, and
H+.
This enzyme belongs to the family of
oxidoreductases, specifically those acting on the CH-OH group of donor with NAD
+ or NADP
+ as acceptor. This enzyme participates in
sphingolipid metabolism.
Tissue distribution
Follicular lymphoma variant translocation 1 is a secreted protein which is weakly expressed in
hematopoietic
Haematopoiesis (, from Greek , 'blood' and 'to make'; also hematopoiesis in American English; sometimes also h(a)emopoiesis) is the formation of blood cellular components. All cellular blood components are derived from haematopoietic stem cells. ...
tissue.
Clinical significance
FVT1 shows a high rate of transcription in some
T cell malignancies and in
phytohemagglutinin-stimulated
lymphocytes. The proximity of FVT1 to
BCL2 suggests that it may participate in the tumoral process.
References
External links
*
Further reading
*
*
*
*
*
EC 1.1.1
NADPH-dependent enzymes
Enzymes of unknown structure
{{1.1.1-enzyme-stub